Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central
nervous system (CNS). It is essential for the development of the CNS and for neuronal …

BackgroundKetamine and non-ketamine N-methyl-d-aspartate receptor antagonists
(NMDAR antagonists) recently demonstrated antidepressant efficacy for the treatment of …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of
neuronal adaptation, is disrupted in mood disorders and in animal models of stress. Here we …

Adult hippocampal neurogenesis is stimulated by chronic administration of antidepressants
(ADs) and by voluntary exercise. Neural progenitor cells (NPCs) in the dentate gyrus (DG) …

BACKGROUND: Chromatin remodeling, including changes in histone acetylation, might
play a role in the pathophysiology and treatment of depression. We investigated whether the …

The brain‐derived neurotrophic factor, BDNF, was discovered more than 30 years ago and,
like other members of the neurotrophin family, this neuropeptide is synthetized as a …

Neurotrophic factors are essential contributors to the survival of peripheral and central
nervous system (CNS) neurons, and demonstration of their reduced availability in diseased …

Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …