Mucus is tenacious. It sticks to most particles, preventing their penetration to the epithelial
surface. Multiple low-affinity hydrophobic interactions play a major role in these adhesive …

Inflammatory lung diseases like asthma bronchiale, chronic obstructive pulmonary disease
and allergic airway inflammation are widespread public diseases that constitute an …

Cystic fibrosis (CF) lung disease reflects the failure of airways defense against chronic
bacterial infection. Studies of CF cultures, transgenic mice, and CF patients suggest that the …

In chronic obstructive pulmonary disease (COPD), exacerbations are generally associated
with several causes, including pollutants, viruses, bacteria that are responsible for an excess …

Delivering therapeutic agents to the lungs requires a deep understanding of the kinetics and
dynamics of drugs in this biologically and physiologically complex system. In this chapter …

Epithelial Na+ channels facilitate the transport of Na+ across high resistance epithelia.
Proteolytic cleavage has an important role in regulating the activity of these channels by …

Background Whereas cilia damage and reduced cilia beat frequency have been implicated
as causative of reduced mucociliary clearance in smokers, theoretically mucociliary …

The ability to maintain proper airway surface liquid (ASL) volume homeostasis is vital for
mucus hydration and clearance, which are essential aspects of the mammalian lung's innate …

Cystic fibrosis (CF) lung disease involves chronic bacterial infection of retained airway
secretions (mucus). Recent data suggest that CF lung disease pathogenesis reflects the …

Inspired air humidification has been reported to show some benefit in bronchiectatic
patients. We have investigated the possibility that one effect might be to enhance …