Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease | New England Journal of
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Most patients with chronic obstructive pulmonary disease (COPD) have at least one
additional, clinically relevant chronic disease. Those with the most severe airflow obstruction …

Attempts to define concepts and things date back to the time of Aristotle, around 2,400 years
ago, when he proposed that a definition should state the essential nature or being of …

This study aimed to describe the prevalence of comorbidities associated with chronic
obstructive pulmonary disease (COPD) and their relation with relevant outcomes. A …

Rationale: Cigarette smoke (CS) inhalation triggers oxidative stress and inflammation,
leading to accelerated lung aging, apoptosis, and emphysema, as well as systemic …

Life expectancy has increased, partly due to significant improvements in the treatment of
communicable diseases. This has resulted in an epidemiologic transition from early mortality …

Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines,
growth factors, and remodeling proteins (senescence-associated secretory phenotype; …

Aging-related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's
disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are …

Aging is progressive physiological degeneration and consequently declined function, which
is linked to senescence on both cellular and organ levels. Accumulating studies indicate that …

Objectives. 1. To review and discuss available evidence supporting that spirometry is an
overlooked global health marker, that could be used regularly through the lifespan to …