Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …

In single-particle cryo-electron microscopy (cryo-EM), molecules suspended in a thin
aqueous layer are rapidly frozen and imaged at cryogenic temperature in the transmission …

Melatonin receptors (MT1 and MT2 in humans) are family AG protein–coupled receptors that
respond to the neurohormone melatonin to regulate circadian rhythm and sleep. Numerous …

The particulate methane monooxygenase (pMMO) is the first enzyme in the C1 metabolic
pathway in methanotrophic bacteria. As this enzyme converts methane into methanol …

The posttranscriptional modifications of tRNA's anticodon stem and loop (ASL) domain
represent a third level, a third code, to the accuracy and efficiency of translating mRNA …

GPR88 is an orphan class A G-protein-coupled receptor that is highly expressed in the
striatum and regulates diverse brain and behavioral functions. Here we present cryo-EM …

Translation elongation is a highly coordinated, multistep, multifactor process that ensures
accurate and efficient addition of amino acids to a growing nascent-peptide chain encoded …

In the past 4 years, because of the advent of new cameras, many ribosome structures have
been solved by cryoelectron microscopy (cryo-EM) at high, often near-atomic resolution …

Phage-antibiotic synergy (PAS) represents a superior treatment strategy for pathogen
infections with less probability of resistance development. Here, we aim to understand the …

Ribosomal RNA (rRNA) from all organisms undergoes post-transcriptional modifications that
increase the diversity of its composition and activity. In mitochondria, specialized …