Background The 22‐item sino‐nasal outcome test (SNOT‐22) is a widely used and powerful
patient‐reported outcomes measure for chronic rhinosinusitis (CRS). More recently; …

Chronic rhinosinusitis (CRS) is nearly ubiquitous in patients with cystic fibrosis (CF). CF
CRS is a challenging entity to define, diagnose, and treat, as patients often have severe …

Background Elexacaftor-tezacaftor-ivacaftor is a highly effective modulator for cystic fibrosis
(CF) patients homozygous or heterozygous for F508del. Effects of the drug on sinonasal …

Rationale: Elexacaftor, tezacaftor, and ivacaftor (ETI) in triple combination improves
pulmonary health for people with cystic fibrosis (PwCF). However, its impact on objective …

Background Cystic fibrosis (CF) is a multisystem disease that often requires otolaryngology
care. Individuals with CF commonly have chronic rhinosinusitis but also present with hearing …

2. Methods Starting in August 2019, adult PwCF (≥ 18 years of age) with CRS who clinically
initiated ETI were enrolled in a prospective, observational study [7]. All participants provided …

Objectives Cystic fibrosis (CF) is characterized by infection and inflammation of the
sinorespiratory tract. Functional endoscopic sinus surgery (FESS) is an option for patients …

Keywords: cystic fibrosis; CFTR modulator; elexacaftor; tezacaftor; ivacaftor; chronic
rhinosinusitis; sinus surgery; SNOT-22 EN cystic fibrosis CFTR modulator elexacaftor …

Background: Primary ciliary dyskinesia (PCD; MIM 242650) is a rare genetic disorder
characterized by malfunction of the motile cilia resulting in reduced mucociliary clearance of …

Objective Cystic fibrosis (CF) patients commonly develop chronic rhinosinusitis (CRS). The
impact of the most common cystic fibrosis transmembrane conductance regulator (CFTR) …