Electronic health records and polygenic risk scores for predicting disease risk
Accurate prediction of disease risk based on the genetic make-up of an individual is
essential for effective prevention and personalized treatment. Nevertheless, to date …
essential for effective prevention and personalized treatment. Nevertheless, to date …
Gene selection by incorporating genetic networks into case-control association studies
Large-scale genome-wide association studies (GWAS) have been successfully applied to a
wide range of genetic variants underlying complex diseases. The network-based regression …
wide range of genetic variants underlying complex diseases. The network-based regression …
TWAS-GKF: A Novel Method for Causal Gene Identification in Transcriptome-wide Association Studies with Knockoff Inference
A Wang, P Tian, YD Zhang - Bioinformatics, 2024 - academic.oup.com
Motivation Transcriptome-wide association study (TWAS) aims to identify trait-associated
genes regulated by significant variants to explore the underlying biological mechanisms at a …
genes regulated by significant variants to explore the underlying biological mechanisms at a …
SAT: a Surrogate-Assisted Two-wave case boosting sampling method, with application to EHR-based association studies
X Liu, J Chubak, RA Hubbard… - Journal of the American …, 2022 - academic.oup.com
Abstract Objectives Electronic health records (EHRs) enable investigation of the association
between phenotypes and risk factors. However, studies solely relying on potentially error …
between phenotypes and risk factors. However, studies solely relying on potentially error …
A novel method for multiple phenotype association studies based on genotype and phenotype network
Joint analysis of multiple correlated phenotypes for genome-wide association studies
(GWAS) can identify and interpret pleiotropic loci which are essential to understand …
(GWAS) can identify and interpret pleiotropic loci which are essential to understand …
[HTML][HTML] mixWAS: An efficient distributed algorithm for mixed-outcomes genome-wide association studies
Genome-wide association studies (GWAS) have been instrumental in identifying genetic
associations for various diseases and traits. However, uncovering genetic underpinnings …
associations for various diseases and traits. However, uncovering genetic underpinnings …
Gene-based association tests using GWAS summary statistics and incorporating eQTL
Although genome-wide association studies (GWAS) have been successfully applied to a
variety of complex diseases and identified many genetic variants underlying complex …
variety of complex diseases and identified many genetic variants underlying complex …
Statistical methods for gene selection and genetic association studies
X Cao - 2023 - search.proquest.com
Michigan Tech Dissertation Template Page 1 STATISTICAL METHODS FOR GENE SELECTION
AND GENETIC ASSOCIATION STUDIES By Xuewei Cao A DISSERTATION Submitted in partial …
AND GENETIC ASSOCIATION STUDIES By Xuewei Cao A DISSERTATION Submitted in partial …
Evaluation of phenotyping errors on polygenic risk score predictions
Accurate disease risk prediction is essential in healthcare to provide personalized disease
prevention and treatment strategies not only to the patients, but also to the general …
prevention and treatment strategies not only to the patients, but also to the general …
Gene-Based Association Tests Using GWAS Summary Statistics and Incorporating eQTL
X Cao, X Wang, S Zhang, Q Sha - 2021 - researchsquare.com
Although genome-wide association studies (GWAS) have been successfully applied to a
variety of complex diseases and identified many genetic variants underlying complex …
variety of complex diseases and identified many genetic variants underlying complex …