The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades
of biochemistry and genetics combined with recent structural studies of the spliceosome …

Precursor messenger RNA (pre-mRNA) splicing is an essential step in the flow of
information from DNA to protein in all eukaryotes. Research over the past four decades has …

In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …

Upon binding double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) is activated
and initiates the cGAS-stimulator of IFN genes (STING)-type I interferon pathway. DEAD-box …

Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its
regulation. Whereas most RNP enzymes are stable in composition and harbor preformed …

Mutations in genes that encode RNA-binding proteins (RBPs) have emerged as critical
determinants of neurological diseases, especially motor neuron disorders such as …

Mechanistic understanding of pre-mRNA splicing requires detailed structural information on
various states of the spliceosome. Here we report the cryo electron microscopy (cryo-EM) …

RNAs in cells are associated with RNA-binding proteins (RBPs) to form ribonucleoprotein
(RNP) complexes. The RBPs influence the structure and interactions of the RNAs and play …

Pre–messenger RNA (pre-mRNA) splicing is carried out by the spliceosome, which
undergoes an intricate assembly and activation process. Here, we report an atomic structure …

Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively
degrades mRNAs harboring premature termination (nonsense) codons. If translated, these …