Background Because of their differentiation potential, pluripotent stem cells can generate
virtually any cell type and, as such, can be used to model development and disease and …

One of the major applications of tissue‐engineered skin substitutes for wound healing is to
promote the healing of cutaneous wounds. In this respect, many important clinical …

The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

Stem cells represent natural units of embryonic development and tissue regeneration.
Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity …

Impaired wound healing is a frequent and very severe problem in patients with diabetes
mellitus, yet little is known about the underlying pathomechanisms. In this paper we review …

The mammalian hair follicle arises during embryonic development from coordinated
interactions between the epidermis and dermis. It is currently unclear how to recapitulate …

Background Cell therapy for large burns is dependent upon autologous epidermis
reconstructed in vitro. However, the effectiveness of current procedures is limited by the …

The global volume of skin damage or injuries has major healthcare implications and,
accounts for about half of the world's annual expenditure in the healthcare sector. In the last …

The fundamental skin role is to supply a supportive barrier to protect body against harmful
agents and injuries. Three layers of skin including epidermis, dermis and hypodermis form a …

The field of epidermal stem cells has dramatically advanced in the last decade, leading to a
better understanding of the molecular factors, signalling pathways and cellular events that …