Methods for non-invasive prenatal ploidy calling

M Rabinowitz, G Gemelos, M Banjevic, A Ryan… - US Patent …, 2024 - Google Patents
The present disclosure provides methods for determining the ploidy status of a chromosome
in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising …

Methods for cancer detection and monitoring

B Zimmermann, R Salari, R Swenerton, HT Wu… - US Patent …, 2024 - Google Patents
The invention provides methods for detecting single nucleotide variants in breast cancer,
bladder cancer, or colorectal cancer. Additional methods and compositions, such as reaction …

Methods and compositions for determining ploidy

HE Kirkizlar, R Salari, S Sigurjonsson… - US Patent …, 2024 - Google Patents
The invention provides improved methods, compositions, and kits for detecting ploidy of
chromosome regions, eg for detecting cancer or a chromosomal abnormality in a gestating …

Methods for amplification of cell-free DNA using ligated adaptors and universal and inner target-specific primers for multiplexed nested PCR

M Rabinowitz, M Hill, B Zimmermann, J Baner… - US Patent …, 2023 - Google Patents
Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses
genetic measurements made on plasma taken from a pregnant mother, along with genetic …

Detecting mutations and ploidy in chromosomal segments

J Babiarz, TP Constantin, LA Eubank… - US Patent …, 2022 - Google Patents
First worldwide family litigation filed litigation https://patents. darts-ip. com/? family=
57221528&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Methods for simultaneous amplification of target loci

J Babiarz, TP Constantin, LA Eubank… - US Patent …, 2024 - Google Patents
The invention provides methods for simultaneously amplifying multiple nucleic acid regions
of interest in one reaction volume as well as methods for selecting a library of primers for use …