Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …

Despite several decades of intense research focused on understanding function (s) and
disease-associated malfunction of p53, there is no sign of any “mid-life crisis” in this rapidly …

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

DNA damage has been long recognized as causal factor for cancer development. When
erroneous DNA repair leads to mutations or chromosomal aberrations affecting oncogenes …

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the
limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has …

DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these
agents induce a plethora of different DNA lesions, it is firstly important to identify the specific …

Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an
early cellular response to the induction of DNA double-strand breaks. Detection of this …

Platinum-based drugs, and in particular cis-diamminedichloroplatinum (II)(best known as
cisplatin), are employed for the treatment of a wide array of solid malignancies, including …

Cisplatin is one of the most widely used and most potent chemotherapy drugs. However,
side effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the use …