Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals
and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon …

Sildenafil, approved two decades ago, is the inhibitor of phosphodiesterase 5 (PDE5). First
of all, it was designated for angina pectoris, but soon it showed a wonderful efficacy in …

Abstract Phosphodiesterase-5 (PDE5) inhibitors are suggested to have anti-tumor effects
and to inhibit surgery-induced immunosuppression. We aimed to explore whether post …

Age-related cognitive decline is accompanied by an increase of neuronal apoptosis and a
dysregulation of neuroplasticity-related molecules such as brain-derived neurotrophic factor …

Pomegranate seed oil, extracted from pomegranate seeds, is a slightly fragrant yellow oil
with a mild odor. Pomegranate seed oil is the main source of punicic acid (conjugated …

Metabolic diseases have a tremendous impact on human morbidity and mortality. Numerous
targets regulating adenosine monophosphate kinase (AMPK) have been identified for …

Introduction Caffeine is an adrenergic antagonist that enhances neuronal activity.
Psychological stress depresses cognitive function. Aim To investigate the effects of acute …

Sildenafil is the first phosphodiesterase-5 inhibitor used for the treatment of erectile
dysfunction. However, recent studies have been suggesting an antitumor effect of sildenafil …

Severe burn induces biochemical mediators such as reactive oxygen species that leads to
lipid peroxidation which may have a key role in formation of acute lung injury (ALI). Sildenafil …

Mucosal balance impairment, bacterial over-proliferation, cytokines, inflammatory mediators
are known as responsible for inflammatory bowel disease. Besides known anorexigenic …