Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

M Mehta, D Tewari, G Gupta, R Awasthi, H Singh… - Chemico-biological …, 2019 - Elsevier
Oligonucleotide-based therapies are advanced novel interventions used in the management
of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease …

Spheroids as a type of three-dimensional cell cultures—examples of methods of preparation and the most important application

K Białkowska, P Komorowski, M Bryszewska… - International journal of …, 2020 - mdpi.com
Cell cultures are very important for testing materials and drugs, and in the examination of
cell biology and special cell mechanisms. The most popular models of cell culture are two …

Physicochemical properties affecting the fate of nanoparticles in pulmonary drug delivery

Q Liu, J Guan, L Qin, X Zhang, S Mao - Drug discovery today, 2020 - Elsevier
Highlights•Clearance routes of nanoparticles in the lung are presented.•Factors influencing
nanoparticle transaction are discussed.•Physicochemical properties of the nanoparticles …

Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Advanced therapeutic strategies for chronic lung disease using nanoparticle-based drug delivery

JY Yhee, J Im, RS Nho - Journal of clinical medicine, 2016 - mdpi.com
Chronic lung diseases include a variety of obstinate and fatal diseases, including asthma,
chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), idiopathic pulmonary …

Chondrocyte spheroids laden in GelMA/HAMA hybrid hydrogel for tissue-engineered cartilage with enhanced proliferation, better phenotype maintenance, and natural …

G Wang, Y An, X Zhang, P Ding, H Bi, Z Zhao - Gels, 2021 - mdpi.com
Three-dimensional cell-laden tissue engineering has become an extensive research
direction. This study aimed to evaluate whether chondrocyte spheroids (chondro-spheroids) …

Polymer-drug conjugates as inhalable drug delivery systems: A review

N Marasini, S Haque, LM Kaminskas - Current Opinion in Colloid & …, 2017 - Elsevier
Accelerating interest by the pharmaceutical industry in the identification and development of
less invasive routes of nanomedicine administration, coupled with defined efforts to improve …

Conjugation to poly (amidoamine) dendrimers and pulmonary delivery reduce cardiac accumulation and enhance antitumor activity of doxorubicin in lung metastasis

Q Zhong, ER Bielski, LS Rodrigues… - Molecular …, 2016 - ACS Publications
Lung is one of the most common sites to which almost all other primary tumors metastasize.
The major challenges in the chemotherapy of lung metastases include the low drug …

Nanostructures for drug delivery in respiratory diseases therapeutics: Revision of current trends and its comparative analysis

LÁ Ibarra-Sánchez, A Gámez-Méndez… - Journal of Drug Delivery …, 2022 - Elsevier
Respiratory diseases are leading causes of death and disability in developing and
developed countries. The burden of acute and chronic respiratory diseases has been rising …

Nano-therapeutics for the lung: state-of-the-art and future perspectives

R Iyer, C CW Hsia, KT Nguyen - Current pharmaceutical …, 2015 - ingentaconnect.com
Inhalation of aerosolized compounds is a popular, non-invasive route for the targeted
delivery of therapeutic molecules to the lung. Various types of nanoparticles have been used …