An increase in intracellular Ca 2+ is the primary trigger of contraction of gastrointestinal (GI)
smooth muscles. However, increasing the Ca 2+ sensitivity of the myofilaments by elevating …

Background Data on the neuromodulatory effects of brain‐derived neurotrophic factor
(BDNF) in the gastrointestinal tract were recently reported, but there are still no data on the …

Aging can lead to rectoanal incontinence due to internal anal sphincter (IAS) dysfunction,
which is characterized by a decrease in IAS tone and contractility and an increase in …

Anal sphincter incontinence is a chronic disease, which dramatically impairs quality of life
and induces high costs for the society. Surgery, considered as the best curative option …

Presently, there are no studies examining the neuromodulatory effects of brain-derived
neurotropic factor (BDNF) on the basal internal anal sphincter (IAS) tone and nonadrenergic …

IT IS WELL KNOWN that smooth muscle contraction, whether spontaneous or following
pharmacological stimulation, occurs in two phases: the initial phasic followed by the tonic …

A comprehensive genomic and proteomic, computational, and physiological approach was
employed to examine the (previously unexplored) role of microRNAs (miRNAs) as …

Aim To analyse the effects of angiotensin II (Ang II) on the contractility of human sigmoid
colon, and to characterize the subtype (s) of receptor (s) involved and the related action …

In these studies, we developed a novel approach of in vivo magnetofection for localized
delivery of nucleic acids such as micro-RNA-139-5p (miR-139-5p; which is known to target …

Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor
in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated …