E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the
turnover and activity of many target proteins. Together with ubiquitinactivating enzyme El …

The SCF (Skp1, Cullins, F-box proteins) multisubunit E3 ubiquitin ligase, also known as CRL
(Cullin-RING ubiquitin Ligase) is the largest E3 ubiquitin ligase family that promotes the …

Heme oxygenase-1 (HO-1) is emerging as an important cytoprotective enzyme system in a
variety of injury models. To optimize future therapeutic applications of HO-1, it is necessary …

E3 ubiquitin ligases are a large family of proteins that can be classified into three major
structurally distinct types: N-end rule E3s, E3s containing the HECT (Homology to E6AP C …

The SCF (Skp1–cullin–F-box proteins), also known as CRL (cullin-based RING ligase), is
the largest family of E3 ubiquitin ligases that mediate approximately 20% ubiquitinated …

Abstract SAG (Sensitive to Apoptosis Gene), also known as RBX2 (RING box protein 2),
ROC2 (Regulator of Cullins 2), or RNF7 (RING Finger Protein 7), was originally cloned in …

Purpose: Sensitive to apoptosis gene (SAG; also known as RBX2 or ROC2) was originally
cloned as a redox-inducible antioxidant protein and was later characterized as a RING …

Abstract Skp1-cullin-F-box protein (SCF) is a multicomponent E3 ubiquitin (Ub) ligase that
ubiquitinates a number of important biologic molecules such as p27, β-catenin, and lκB for …

SAG (sensitive to apoptosis gene) or ROC2/RBX2 is the second family member of
ROC1/RBX1, a component of SCF (Skp1, Cullin, F-box protein) and VCB (von Hippel …

Although astragaloside IV, a saponin isolated from Astragalus membranaceus, has been
shown to protect the myocardium against ischemia/reperfusion injury, its effect on the status …