Nanoparticle-based delivery systems for vaccines
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional
vaccinations may have low immunogenicity and, in most situations, only provide partial …
vaccinations may have low immunogenicity and, in most situations, only provide partial …
Exosome-based vaccines: history, current state, and clinical trials
P Santos, F Almeida - Frontiers in immunology, 2021 - frontiersin.org
Extracellular vesicles (EVs) are released by most cell types as part of an intracellular
communication system in crucial processes such as inflammation, cell proliferation, and …
communication system in crucial processes such as inflammation, cell proliferation, and …
Technical challenges of working with extracellular vesicles
Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with
potential applications in diagnosis, prognosis and therapeutic guidance in most pathological …
potential applications in diagnosis, prognosis and therapeutic guidance in most pathological …
Extracellular vesicle-mediated communication within host-parasite interactions
Z Wu, L Wang, J Li, L Wang, Z Wu, X Sun - Frontiers in immunology, 2019 - frontiersin.org
Extracellular vesicles (EVs) are small membrane-surrounded structures released by different
kinds of cells (normal, diseased, and transformed cells) in vivo and in vitro that contain large …
kinds of cells (normal, diseased, and transformed cells) in vivo and in vitro that contain large …
Hookworm secreted extracellular vesicles interact with host cells and prevent inducible colitis in mice
RM Eichenberger, S Ryan, L Jones, G Buitrago… - Frontiers in …, 2018 - frontiersin.org
Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal
harm to their hosts, allowing them to establish chronic infections. This is mediated by …
harm to their hosts, allowing them to establish chronic infections. This is mediated by …
[HTML][HTML] Helminth parasites and immune regulation
PH Gazzinelli-Guimaraes, TB Nutman - F1000Research, 2018 - ncbi.nlm.nih.gov
Helminth parasites are complex metazoans that belong to different taxonomic families but
that collectively share the capacity to downregulate the host immune response directed …
that collectively share the capacity to downregulate the host immune response directed …
[HTML][HTML] The protein and microRNA cargo of extracellular vesicles from parasitic helminths–current status and research priorities
J Sotillo, MW Robinson, MJ Kimber, M Cucher… - International journal for …, 2020 - Elsevier
Helminth parasites have a remarkable ability to persist within their mammalian hosts, which
is largely due to their secretion of molecules with immunomodulatory properties. Although …
is largely due to their secretion of molecules with immunomodulatory properties. Although …
Immunomodulation by helminths: intracellular pathways and extracellular vesicles
A Zakeri, EP Hansen, SD Andersen… - Frontiers in …, 2018 - frontiersin.org
Helminth parasites are masters at manipulating host immune responses, using an array of
sophisticated mechanisms. One of the major mechanisms enabling helminths to establish …
sophisticated mechanisms. One of the major mechanisms enabling helminths to establish …
Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism
Schistosome infection persists for decades. Parasites are in close contact with host
peripheral blood immune cells, yet little is known about the regulatory interactions between …
peripheral blood immune cells, yet little is known about the regulatory interactions between …
Vesicle-based secretion in schistosomes: Analysis of protein and microRNA (miRNA) content of exosome-like vesicles derived from Schistosoma mansoni
V Samoil, M Dagenais, V Ganapathy, J Aldridge… - Scientific reports, 2018 - nature.com
Exosomes are small vesicles of endocytic origin, which are released into the extracellular
environment and mediate a variety of physiological and pathological conditions. Here we …
environment and mediate a variety of physiological and pathological conditions. Here we …