Nanoparticle-based delivery systems for vaccines

R Bezbaruah, VP Chavda, L Nongrang, S Alom… - Vaccines, 2022 - mdpi.com
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional
vaccinations may have low immunogenicity and, in most situations, only provide partial …

Exosome-based vaccines: history, current state, and clinical trials

P Santos, F Almeida - Frontiers in immunology, 2021 - frontiersin.org
Extracellular vesicles (EVs) are released by most cell types as part of an intracellular
communication system in crucial processes such as inflammation, cell proliferation, and …

Technical challenges of working with extracellular vesicles

MI Ramirez, MG Amorim, C Gadelha, I Milic, JA Welsh… - Nanoscale, 2018 - pubs.rsc.org
Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with
potential applications in diagnosis, prognosis and therapeutic guidance in most pathological …

Extracellular vesicle-mediated communication within host-parasite interactions

Z Wu, L Wang, J Li, L Wang, Z Wu, X Sun - Frontiers in immunology, 2019 - frontiersin.org
Extracellular vesicles (EVs) are small membrane-surrounded structures released by different
kinds of cells (normal, diseased, and transformed cells) in vivo and in vitro that contain large …

Hookworm secreted extracellular vesicles interact with host cells and prevent inducible colitis in mice

RM Eichenberger, S Ryan, L Jones, G Buitrago… - Frontiers in …, 2018 - frontiersin.org
Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal
harm to their hosts, allowing them to establish chronic infections. This is mediated by …

[HTML][HTML] Helminth parasites and immune regulation

PH Gazzinelli-Guimaraes, TB Nutman - F1000Research, 2018 - ncbi.nlm.nih.gov
Helminth parasites are complex metazoans that belong to different taxonomic families but
that collectively share the capacity to downregulate the host immune response directed …

[HTML][HTML] The protein and microRNA cargo of extracellular vesicles from parasitic helminths–current status and research priorities

J Sotillo, MW Robinson, MJ Kimber, M Cucher… - International journal for …, 2020 - Elsevier
Helminth parasites have a remarkable ability to persist within their mammalian hosts, which
is largely due to their secretion of molecules with immunomodulatory properties. Although …

Immunomodulation by helminths: intracellular pathways and extracellular vesicles

A Zakeri, EP Hansen, SD Andersen… - Frontiers in …, 2018 - frontiersin.org
Helminth parasites are masters at manipulating host immune responses, using an array of
sophisticated mechanisms. One of the major mechanisms enabling helminths to establish …

Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism

J Liu, L Zhu, J Wang, L Qiu, Y Chen, RE Davis… - PLoS …, 2019 - journals.plos.org
Schistosome infection persists for decades. Parasites are in close contact with host
peripheral blood immune cells, yet little is known about the regulatory interactions between …

Vesicle-based secretion in schistosomes: Analysis of protein and microRNA (miRNA) content of exosome-like vesicles derived from Schistosoma mansoni

V Samoil, M Dagenais, V Ganapathy, J Aldridge… - Scientific reports, 2018 - nature.com
Exosomes are small vesicles of endocytic origin, which are released into the extracellular
environment and mediate a variety of physiological and pathological conditions. Here we …