Synthetic approaches to the new drugs approved during 2022
SP France, EA Lindsey, EL McInturff… - Journal of Medicinal …, 2024 - ACS Publications
In 2022, 23 new small molecule chemical entities were approved as drugs by the United
States FDA, European Union EMA, Japan PMDA, and China NMPA. This review describes …
States FDA, European Union EMA, Japan PMDA, and China NMPA. This review describes …
One‐pot syntheses of α, β‐unsaturated carbonyl compounds through palladium‐mediated dehydrogenation of ketones, aldehydes, esters, lactones and amides
J Muzart - European Journal of Organic Chemistry, 2010 - Wiley Online Library
This review highlights the different direct stoichiometric and catalytic palladium procedures
leading to α, β‐unsaturated carbonyl compounds from the corresponding ketones …
leading to α, β‐unsaturated carbonyl compounds from the corresponding ketones …
[图书][B] Transition metal reagents and catalysts: innovations in organic synthesis
J Tsuji - 2002 - books.google.com
Transition Metal Reagents and Catalysts Innovations in Organic Synthesis Jiro Tsuji
Emeritus Professor, Tokyo Institute of Technology, Japan Numerous innovative and practical …
Emeritus Professor, Tokyo Institute of Technology, Japan Numerous innovative and practical …
New general synthetic methods involving π-allylpalladium complexes as intermediates and neutral reaction conditions
J Tsuji - Tetrahedron, 1986 - Elsevier
We have reported in 1965 that n-allylpalfadium chloride (1) reacts with C-nucleophiles such
as malonates, acetoacetates, and enamines (Eq. l), and shown that the reaction offers a new …
as malonates, acetoacetates, and enamines (Eq. l), and shown that the reaction offers a new …
New synthetic reactions of allyl alkyl carbonates, allyl. beta.-keto carboxylates, and allyl vinylic carbonates catalyzed by palladium complexes
J Tsuji, I Minami - Accounts of Chemical Research, 1987 - ACS Publications
In 1965 we reported that (ir-allyl) palladium chloride reacts with carbonucleophiles such as
malonates, acetoacetates, and enamines, thereby offering a new method for carbon-carbon …
malonates, acetoacetates, and enamines, thereby offering a new method for carbon-carbon …
A simple, effective, new, palladium-catalyzed conversion of enol silanes to enones and enals
RC Larock, TR Hightower, GA Kraus, P Hahn… - Tetrahedron letters, 1995 - Elsevier
0 OSiMe3 0"9 ~ Page 1 Pergamon 0040-4039(95)00306-1 Tetrahedron Letters, Vol. 36, No. 14,
pp. 2423-2426, 1995 Elsevier Science Ltd Printed in Great Britain 0040-4039/95 $9.50+0.00 A …
pp. 2423-2426, 1995 Elsevier Science Ltd Printed in Great Britain 0040-4039/95 $9.50+0.00 A …
Asymmetric deprotonation of prochiral ketones using chiral lithium amide bases
CM Cain, RPC Cousins, G Coumbarides, NS Simpkins - Tetrahedron, 1990 - Elsevier
A number of chiral secondary amines have been prepared and used as precursors to the
corresponding chiral lithium amide bases. Treatment of either cis-2, 6 …
corresponding chiral lithium amide bases. Treatment of either cis-2, 6 …
A New and One-Pot Synthesis of α,β-Unsaturated Ketones by Dehydrogenation of Various Ketones with N-tert-Butyl Phenylsulfinimidoyl Chloride
T Mukaiyama, J Matsuo, H Kitagawa - Chemistry letters, 2000 - academic.oup.com
A New and One-Pot Synthesis of α,β-Unsaturated Ketones by Dehydrogenation of Various
Ketones with N-tert-Butyl Phenylsulfinimi Page 1 α,β-Unsaturated ketones were synthesized by …
Ketones with N-tert-Butyl Phenylsulfinimi Page 1 α,β-Unsaturated ketones were synthesized by …
New synthetic methods for α, β-unsaturated ketones, aldehydes, esters and lactones by the palladium-catalyzed reactions of silyl enol ethers, ketene silyl acetals, and …
I Minami, K Takahashi, I Shimizu, T Kimura, J Tsuji - Tetrahedron, 1986 - Elsevier
Silyl enol ethers and ketene silyl acetals derived from ketones, aldehydes, esters and
lactones are converted into α, β-unsaturated ketones, aldehydes, esters and lactones by …
lactones are converted into α, β-unsaturated ketones, aldehydes, esters and lactones by …
Catalytic incorporation of CO2 into organic substrates: Synthesis of unsaturated carbamates, carbonates and ureas
C Bruneau, PH Dixneuf - Journal of molecular catalysis, 1992 - Elsevier
The electrophilic activation of alkynes toward nucleophilic adducts of CO 2 allows the
catalytic incorporation of carbon dioxide to produce functional substrates that are usually …
catalytic incorporation of carbon dioxide to produce functional substrates that are usually …