The phosphoinositide 3-kinase (PI3K) pathway plays an integral role in many cellular
processes and is frequently altered in cancer, contributing to tumor growth and survival …

Abstract The phosphoinositide 3-kinase (PI3K) pathway is a key signal transduction system
that links oncogenes and multiple receptor classes to many essential cellular functions, and …

Almost thirty years ago, PI3K was discovered as a lipid kinase associated with certain
oncoproteins. The first decade of research on PI3K saw the identification, purification and …

There have long been indications of a role for PI3K (phosphatidylinositol 3-kinase) in cancer
pathogenesis. Experimental data document a requirement for deregulation of both …

The involvement of the PIK3CA gene product p110α, the catalytic subunit of
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …

Until recently, non–small-cell lung cancer (NSCLC) was treated as a single disease despite
recognition of its histologic and molecular heterogeneity. Recent clinical trials, however …

Lung cancer is a common disease with more than 1.6 million new cases diagnosed
worldwide in 2008. Treatments for patients with advanced disease are rarely curative, and …

Non-small cell lung cancer (NSCLC) is a devastating disease with poor prognosis. Systemic
chemotherapy has been the mainstay of treatment in advanced disease for many decades …

Background: The activity of the protein kinase Akt is frequently dysregulated in cancer and is
an important factor in the growth and survival of tumour cells. Akt activation involves the …

Purpose PIK3CA gene encoding a catalytic subunit of the phosphatidylinositol-3-kinase
(PI3K) is mutated and/or amplified in various neoplasia, including lung cancer. Here we …