Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …

Abstract Salsolinol (1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline) is a
tetrahydroisoquinoline derivative whose presence in humans was first detected in the urine …

Throughout the world, ethanol is both an important commercial commodity and a source of
major medical and social problems. Ethanol readily passes through biological membranes …

Over the past two decades, the opioid epidemic in the United States and Canada has
evidenced the need for a better understanding of the molecular mechanisms of medications …

Cocoa and chocolate, prepared from cocoa beans that originate from the fruits of the cocoa
tree Theobroma cacao, have a long-standing reputation as healthy food, including mood …

This paper is the fortieth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Abstract The 1, 2, 3, 4-tetrahydroisoquinolines (TIQs) are compounds frequently described
as alkaloids that can be found in the human body fluids and/or tissues including the brain. In …

Salsolinol (1-methyl-1, 2, 3, 4-tetrahydroisoquinoline-6, 7-diol) is a close structural analogue
of dopamine with an asymmetric center at the C1 position, and its presence in vivo, both in …

Utilizing a simulated gastrointestinal medium which approximates physiological conditions
within the mammalian GI tract, experiments aimed at isolating and identifying unique …

A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first
metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol …