Background Ab initio prediction of splice sites is an essential step in eukaryotic genome
annotation. Recent predictors have exploited Deep Learning algorithms and reliable gene …

Alternative splicing of pre-mRNAs is a crucial mechanism for maintaining protein diversity in
eukaryotes without requiring a considerable increase of genes in the number. Due to rapid …

Alternative splicing (AS) can enhance the adaptive capacity of organisms to respond to
abiotic stresses via transcriptome plasticity; however, the mechanism underlying the …

Background Global concern over the rapid expansion of the Asian tiger mosquito, Aedes
albopictus, and its vector competence has highlighted an urgent need to improve currently …

Pairing of splice sites across an intron or exon is the central point of intron or exon definition
in pre-mRNA splicing with the latter mode proposed for most mammalian exons. However …

At the end of introns, the polypyrimidine tract (Py) is often close to the 3′ AG in a consensus
(Y) 20NC AG gt in humans. Interestingly, we have found that they could also be separated …

Bacterial artificial chromosome (BAC)-based transgenes have emerged as a powerful tool
for controlled and conditional interrogation of protein function in higher eukaryotes. While …

Eukaryotic gene expression is an essential process for proper cell differentiation,
development, and the cell's response to environmental signals. Pre-mRNA splicing is an …

How have the branchpoint motifs evolved in organisms of different complexity? Here we
identified and examined the consensus motifs (R1C2T3R4A5Y6, R: A or G, Y: C or T) of 898 …

Bacterial artificial chromosome (BAC)–based transgenes have emerged as a powerful tool
for controlled and conditional interrogation of protein function in higher eukaryotes. Although …