A highly diverse T-cell receptor (TCR) repertoire is a fundamental property of an effective
immune system, and is associated with efficient control of viral infections and other …

Immune memory responses to previously encountered pathogens can sometimes alter the
immune response to and the course of infection of an unrelated pathogen by a process …

Secretory immunoglobulin A (SIgA) shields the gut epithelium from luminal antigens and
contributes to host-microbe symbiosis. However, how antibody responses are regulated to …

Intestinal immunoglobulin A (IgA) ensures host defense and symbiosis with our commensal
microbiota. Yet previous studies hint at a surprisingly low diversity of intestinal IgA, and it is …

Currently, it is not understood how the specificity of the TCR guides CD4+ T cells into the
conventional lineage (Tconv) vs directing them to become regulatory (Treg) cells defined by …

The main functions of memory T cells are to provide protection upon re‐exposure to a
pathogen and to prevent the re‐emergence of low‐grade persistent pathogens. Memory T …

ABSTRACT T-cell receptors recognize peptides presented by the major histocompatibility
complex (MHC) on the surface of antigen-presenting cells (APC). The ability of the T-cell …

The marked proliferation of activated CD8+ T cells is pathognomonic of EBV-associated
infectious mononucleosis (IM), common in young adults. Since the diversity and size of the …

Why some virus-specific CD8 TCR repertoires are diverse and others restricted or
“oligoclonal” has been unknown. We show here that oligoclonality and extreme clonal …

CD8 T cell cross-reactivity between viruses can play roles in protective heterologous
immunity and damaging immunopathology. This cross-reactivity is sometimes predictable …