Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies

Y Zhang, Q Li, Z Huang, B Li, EC Nice, C Huang, L Wei… - Cancers, 2022 - mdpi.com
Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Glucose metabolic crosstalk and regulation in brain function and diseases

S Zhang, BB Lachance, MP Mattson, X Jia - Progress in neurobiology, 2021 - Elsevier
Brain glucose metabolism, including glycolysis, the pentose phosphate pathway, and
glycogen turnover, produces ATP for energetic support and provides the precursors for the …

CircRPN2 inhibits aerobic glycolysis and metastasis in hepatocellular carcinoma

J Li, ZQ Hu, SY Yu, L Mao, ZJ Zhou, PC Wang, Y Gong… - Cancer Research, 2022 - AACR
Although circular RNAs (circRNA) are known to modulate tumor initiation and progression,
their role in hepatocellular carcinoma (HCC) metastasis remains poorly understood. Here …

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

LE Sanman, Y Qian, NA Eisele, TM Ng… - Elife, 2016 - elifesciences.org
When innate immune cells such as macrophages are challenged with environmental
stresses or infection by pathogens, they trigger the rapid assembly of multi-protein …

When place matters: shuttling of enolase-1 across cellular compartments

M Didiasova, L Schaefer, M Wygrecka - Frontiers in cell and …, 2019 - frontiersin.org
Enolase is a glycolytic enzyme, which catalyzes the inter-conversion of 2-phosphoglycerate
to phosphoenolpyruvate. Altered expression of this enzyme is frequently observed in cancer …

[HTML][HTML] Tumor-intrinsic CD47 signal regulates glycolysis and promotes colorectal cancer cell growth and metastasis

T Hu, H Liu, Z Liang, F Wang, C Zhou, X Zheng… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: CD47 plays a vital role in the immune escape of tumor cells, but its role in
regulating immune-unrelated biological processes such as proliferation and metastasis …

Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation

I Huppertz, JI Perez-Perri, P Mantas, T Sekaran… - Molecular cell, 2022 - cell.com
Differentiating stem cells must coordinate their metabolism and fate trajectories. Here, we
report that the catalytic activity of the glycolytic enzyme Enolase 1 (ENO1) is directly …

[HTML][HTML] Enolase 1, a moonlighting protein, as a potential target for cancer treatment

G Qiao, A Wu, X Chen, Y Tian, X Lin - International journal of …, 2021 - ncbi.nlm.nih.gov
Abstract Enolase 1 (ENO1) is a moonlighting protein, function as a glycolysis enzyme, a
plasminogen receptor and a DNA binding protein. ENO1 play an important role in the …

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells

LF Gemta, PJ Siska, ME Nelson, X Gao, X Liu… - Science …, 2019 - science.org
In the context of solid tumors, there is a positive correlation between the accumulation of
cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) and favorable clinical outcomes …

DeSUMOylation of a Verticillium dahliae enolase facilitates virulence by derepressing the expression of the effector VdSCP8

XM Wu, BS Zhang, YL Zhao, HW Wu, F Gao… - Nature …, 2023 - nature.com
The soil-borne fungus Verticillium dahliae, the most notorious plant pathogen of the
Verticillium genus, causes vascular wilts in a wide variety of economically important crops …