Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies
Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …
Glucose metabolic crosstalk and regulation in brain function and diseases
Brain glucose metabolism, including glycolysis, the pentose phosphate pathway, and
glycogen turnover, produces ATP for energetic support and provides the precursors for the …
glycogen turnover, produces ATP for energetic support and provides the precursors for the …
CircRPN2 inhibits aerobic glycolysis and metastasis in hepatocellular carcinoma
J Li, ZQ Hu, SY Yu, L Mao, ZJ Zhou, PC Wang, Y Gong… - Cancer Research, 2022 - AACR
Although circular RNAs (circRNA) are known to modulate tumor initiation and progression,
their role in hepatocellular carcinoma (HCC) metastasis remains poorly understood. Here …
their role in hepatocellular carcinoma (HCC) metastasis remains poorly understood. Here …
Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death
LE Sanman, Y Qian, NA Eisele, TM Ng… - Elife, 2016 - elifesciences.org
When innate immune cells such as macrophages are challenged with environmental
stresses or infection by pathogens, they trigger the rapid assembly of multi-protein …
stresses or infection by pathogens, they trigger the rapid assembly of multi-protein …
When place matters: shuttling of enolase-1 across cellular compartments
Enolase is a glycolytic enzyme, which catalyzes the inter-conversion of 2-phosphoglycerate
to phosphoenolpyruvate. Altered expression of this enzyme is frequently observed in cancer …
to phosphoenolpyruvate. Altered expression of this enzyme is frequently observed in cancer …
[HTML][HTML] Tumor-intrinsic CD47 signal regulates glycolysis and promotes colorectal cancer cell growth and metastasis
Rationale: CD47 plays a vital role in the immune escape of tumor cells, but its role in
regulating immune-unrelated biological processes such as proliferation and metastasis …
regulating immune-unrelated biological processes such as proliferation and metastasis …
Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation
I Huppertz, JI Perez-Perri, P Mantas, T Sekaran… - Molecular cell, 2022 - cell.com
Differentiating stem cells must coordinate their metabolism and fate trajectories. Here, we
report that the catalytic activity of the glycolytic enzyme Enolase 1 (ENO1) is directly …
report that the catalytic activity of the glycolytic enzyme Enolase 1 (ENO1) is directly …
[HTML][HTML] Enolase 1, a moonlighting protein, as a potential target for cancer treatment
G Qiao, A Wu, X Chen, Y Tian, X Lin - International journal of …, 2021 - ncbi.nlm.nih.gov
Abstract Enolase 1 (ENO1) is a moonlighting protein, function as a glycolysis enzyme, a
plasminogen receptor and a DNA binding protein. ENO1 play an important role in the …
plasminogen receptor and a DNA binding protein. ENO1 play an important role in the …
Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells
In the context of solid tumors, there is a positive correlation between the accumulation of
cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) and favorable clinical outcomes …
cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) and favorable clinical outcomes …
DeSUMOylation of a Verticillium dahliae enolase facilitates virulence by derepressing the expression of the effector VdSCP8
XM Wu, BS Zhang, YL Zhao, HW Wu, F Gao… - Nature …, 2023 - nature.com
The soil-borne fungus Verticillium dahliae, the most notorious plant pathogen of the
Verticillium genus, causes vascular wilts in a wide variety of economically important crops …
Verticillium genus, causes vascular wilts in a wide variety of economically important crops …