Simple Summary Lung adenocarcinoma (LUAD) is the major subtype of lung cancer and
represents the deadliest human cancer, affecting current-, ex-, and even non-smokers …

Macrophages are one of the most abundant leukocyte populations infiltrating tumor tissues
and can exhibit both tumoricidal and tumor-promoting activities. In 1989, we reported the …

Tumor-associated macrophages (TAMs) influence lung tumor development by inducing
immunosuppression. Transcriptome analysis of TAMs isolated from human lung tumor …

Malignant pleural effusion (MPE) is an exudative effusion with malignant cells. MPE is a
common symptom and accompanying manifestation of metastatic disease. It affects up to …

Among the different hallmarks of cancer, deregulation of cellular metabolism turned out to be
an essential mechanism in promoting cancer resistance and progression. The pyruvate …

Lung cancer persists to contribute to one-quarter of cancer-associated deaths. Among the
different histologies, non-small cell lung cancer (NSCLC) alone accounts for 85% of the …

The integrated stress response (ISR) is an essential stress-support pathway increasingly
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in …

The aim of the present study was to investigate combined effects of cold atmospheric plasma
(CAP) and the chemotherapeutic drug doxorubicin (DOX) on murine and human melanoma …

Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that are directly
involved in altered cancer cell metabolism, resulting in cancer aggressiveness and …

Lung adenocarcinoma (LUAD)-derived Wnts increase cancer cell proliferative/stemness
potential, but whether they impact the immune microenvironment is unknown. Here we show …