The role of innate immune cells in the tumor microenvironment and research progress in anti-tumor therapy

C Lu, Y Liu, NM Ali, B Zhang, X Cui - Frontiers in Immunology, 2023 - frontiersin.org
Innate immune cells in the tumor microenvironment (TME) mainly include macrophages,
neutrophils, natural killer cells, dendritic cells and bone marrow derived suppressor cells …

Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review

YY Tang, DC Wang, YQ Wang, AF Huang… - Frontiers in …, 2023 - frontiersin.org
Hypoxia-inducible factor-1α (HIF-1α) is a primary metabolic sensor, and is expressed in
different immune cells, such as macrophage, dendritic cell, neutrophil, T cell, and non …

Metabolic adaptations determine whether natural killer cells fail or thrive within the tumor microenvironment

A Moinuddin, SM Poznanski, AL Portillo… - Immunological …, 2024 - Wiley Online Library
Natural Killer (NK) cells are a top contender in the development of adoptive cell therapies for
cancer due to their diverse antitumor functions and ability to restrict their activation against …

[HTML][HTML] Intrinsic and extrinsic factors determining natural killer cell fate: Phenotype and function

L Zhi, X Wang, Q Gao, W He, C Shang, C Guo… - Biomedicine & …, 2023 - Elsevier
Natural killer (NK) cells are derived from hematopoietic stem cells. They belong to the innate
lymphoid cell family, which is an important part of innate immunity. This family plays a role in …

Pharmacological impact of microRNAs in head and neck squamous cell carcinoma: prevailing insights on molecular pathways, diagnosis, and nanomedicine …

B Bhattacharjee, AF Syeda, D Rynjah… - Frontiers in …, 2023 - frontiersin.org
Head and neck squamous cell carcinoma is a disease that most commonly produce tumours
from the lining of the epithelial cells of the lips, larynx, nasopharynx, mouth, or oro-pharynx. It …

Hypoxic State of Cells and Immunosenescence: A Focus on the Role of the HIF Signaling Pathway

D Troise, B Infante, S Mercuri, GS Netti, E Ranieri… - Biomedicines, 2023 - mdpi.com
Hypoxia activates hypoxia-related signaling pathways controlled by hypoxia-inducible
factors (HIFs). HIFs represent a quick and effective detection system involved in the cellular …

Advances in metabolic reprogramming of NK cells in the tumor microenvironment on the impact of NK therapy

L Miao, C Lu, B Zhang, H Li, X Zhao, H Chen… - Journal of Translational …, 2024 - Springer
Natural killer (NK) cells are unique from other immune cells in that they can rapidly kill
multiple neighboring cells without the need for antigenic pre-sensitization once the cells …

Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review

H Ruan, Q Zhang, Y Zhang, S Li, X Ran - Critical Care, 2024 - Springer
Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory
response triggered by infection, involving multifactorial and intricate molecular mechanisms …

STAT5 Is Necessary for the Metabolic Switch Induced by IL-2 in Cervical Cancer Cell Line SiHa

A Valle-Mendiola, L Rocha-Zavaleta… - International Journal of …, 2024 - mdpi.com
The tumor cells reprogram their metabolism to cover their high bioenergetic demands for
maintaining uncontrolled growth. This response can be mediated by cytokines such as IL-2 …

Immunometabolic Signature during Respiratory Viral Infection: A Potential Target for Host-Directed Therapies

L Menezes dos Reis, MR Berçot, BG Castelucci… - Viruses, 2023 - mdpi.com
RNA viruses are known to induce a wide variety of respiratory tract illnesses, from simple
colds to the latest coronavirus pandemic, causing effects on public health and the economy …