Highlights•MAPK cascades are conserved signaling modules downstream of cell surface
receptors.•Plant perception of endogenous and exogenous signals converges on MAPK …

The c-Jun N-terminal kinases (JNKs) are members of a larger group of serine/threonine
(Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were …

The ubiquitous nature of protein phosphorylation makes it challenging to map kinase-
substrate relationships, which is a necessary step toward defining signaling network …

Mitogen‐activated protein kinase (MAPK) cascades are key signaling modules downstream
of receptors/sensors that perceive either endogenously produced stimuli such as peptide …

The mass spectrometric analysis of protein phosphorylation is still far from being routine,
and the outcomes thereof are often unsatisfying. Apart from the inherent problem of …

Presently, phosphorylation of proteins is the most studied and best understood PTM.
However, the analysis of phosphoproteins and phosphopeptides is still one of the most …

Do kinases cascade? How well is cell regulation understood? What are the best ways to
model regulatory systems? Attempts to answer such questions can have bearings on the …

Reversible protein phosphorylation is a major regulation mechanism of fundamental
biological processes, not only in eukaryotes but also in bacteria. A growing body of evidence …

Poly (ADP-ribose) polymerases (PARPs) catalyze the transfer of multiple adenine
diphosphate ribose (ADP-ribose) units from nicotinamide adenine dinucleotide (NAD) to …

Genes for functional Ser/Thr protein kinases (STPKs) are ubiquitous in prokaryotic genomes,
but little is known about their physiological substrates and their actual involvement in …