[HTML][HTML] Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: pathogenic mechanisms and therapeutic potential
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
Therapeutic potential of vital transcription factors in Alzheimer's and Parkinson's disease with particular emphasis on transcription factor EB mediated autophagy
Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …
[HTML][HTML] Flavonoids: Their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson's disease
Y Açar, D Ağagündüz, P De Cicco… - Biomedicine & …, 2023 - Elsevier
Abstract Parkinson's Disease (PD), a neurodegenerative disorder, is characterized by the
degeneration of progressive dopaminergic (DA) neurons in the substantia nigra region of …
degeneration of progressive dopaminergic (DA) neurons in the substantia nigra region of …
New promising therapeutic avenues of curcumin in brain diseases
Curcumin, the dietary polyphenol isolated from Curcuma longa (turmeric), is commonly used
as an herb and spice worldwide. Because of its bio-pharmacological effects curcumin is also …
as an herb and spice worldwide. Because of its bio-pharmacological effects curcumin is also …
[HTML][HTML] Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy
Abstract Alzheimer's disease (AD), characterized by the accumulation of protein aggregates
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …
Promising drug targets and associated therapeutic interventions in Parkinson's disease
SN Rai, P Singh, R Varshney… - Neural regeneration …, 2021 - journals.lww.com
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …
availability of symptomatic treatments, response towards the health of PD patients remains …
[HTML][HTML] Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease
K Zhang, S Zhu, J Li, T Jiang, L Feng, J Pei… - … Pharmaceutica Sinica B, 2021 - Elsevier
Abstract Parkinson's disease (PD), known as one of the most universal neurodegenerative
diseases, is a serious threat to the health of the elderly. The current treatment has been …
diseases, is a serious threat to the health of the elderly. The current treatment has been …
Brain delivery of curcumin through low-intensity ultrasound-induced blood–brain barrier opening via lipid-plga nanobubbles
Y Yan, Y Chen, Z Liu, F Cai, W Niu, L Song… - International Journal …, 2021 - Taylor & Francis
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Owing
to the presence of blood–brain barrier (BBB), conventional pharmaceutical agents are …
to the presence of blood–brain barrier (BBB), conventional pharmaceutical agents are …
[HTML][HTML] Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: a mechanism review
Neurodegenerative diseases (NDs) are common chronic diseases related to progressive
damage of the nervous system. Globally, the number of people with an ND is dramatically …
damage of the nervous system. Globally, the number of people with an ND is dramatically …
Curcumin and endometriosis
A Vallée, Y Lecarpentier - International journal of molecular sciences, 2020 - mdpi.com
Endometriosis is one of the main common gynecological disorders, which is characterized
by the presence of glands and stroma outside the uterine cavity. Some findings have …
by the presence of glands and stroma outside the uterine cavity. Some findings have …