Although some tumor has become a curable disease for many patients, involvement of the
central nervous system (CNS) is still a major concern. The blood–brain barrier (BBB), a …

The coding regions account for only a small part of the human genome, and the remaining
vast majority of the regions generate large amounts of non-coding RNAs. Although non …

Delivery of effective anti-leukemic agents to the central nervous system (CNS) is considered
essential for cure of childhood acute lymphoblastic leukemia. Current CNS-directed therapy …

Central nervous system (CNS) involvement remains a clinical hurdle in treating childhood B-
cell precursor acute lymphoblastic leukemia (BCP-ALL). The disease mechanisms of CNS …

Simple Summary T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy
arising from the aberrant proliferation of immature T-cell progenitors. Despite improved …

Detailed characterization of the B‐lymphoblastic leukemia (B‐ALL) cells which invade the
central nervous system (CNS) has been limited by practical challenges. To test whether the …

Abstract Treatment and prophylaxis of the central nervous system (CNS) is a standard
component of acute lymphoblastic leukemia (ALL) therapy. However, CNS-directed …