Colon cancer is a major human cancer accounting for about a tenth of all cancer cases thus
making it among the top three cancers in terms of incidence as well as mortality. Metastasis …

Immune cell trafficking is a critical element of the intestinal immune response, both in
homeostasis and in pathological conditions associated with inflammatory bowel disease …

Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota
with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics …

Research into the pathophysiology of psoriasis has shed light onto many fascinating
immunological interactions and underlying genetic constellations. Most prominent among …

The principal targets for anti-chemokine therapy in inflammatory bowel disease (IBD) have
been the receptors CCR9 and CXCR3 and their respective ligands CCL25 and CXCL10 …

Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

A primordial gut-epithelial innate defense response is the release of hydrogen peroxide by
dual NADPH oxidase (DUOX). In inflammatory bowel disease (IBD), a condition …

Hypersecretion of proinflammatory cytokines and dysregulated activation of the IL-23/Th17
axis in response to intestinal microbiota dysbiosis are key factors in the pathogenesis of …

The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a
wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling …

The CCL20/CCR6 axis is implicated in the migration of CCR6+ immune cells towards
CCL20, its sole ligand, whose expression is increased during inflammatory processes and is …