[HTML][HTML] Towards a better understanding of anesthesia emergence mechanisms: Research and clinical implications
M Cascella, S Bimonte, MR Muzio - World journal of methodology, 2018 - ncbi.nlm.nih.gov
Emergence from anesthesia (AE) is the ending stage of anesthesia featuring the transition
from unconsciousness to complete wakefulness and recovery of consciousness (RoC). A …
from unconsciousness to complete wakefulness and recovery of consciousness (RoC). A …
[HTML][HTML] Serotonin decreases the gain of visual responses in awake macaque V1
Serotonin, an important neuromodulator in the brain, is implicated in affective and cognitive
functions. However, its role even for basic cortical processes is controversial. For example …
functions. However, its role even for basic cortical processes is controversial. For example …
[HTML][HTML] Serotonin transporter and plasma membrane monoamine transporter are necessary for the antidepressant-like effects of ketamine in mice
MA Bowman, M Vitela, KM Clarke, W Koek… - International journal of …, 2020 - mdpi.com
Major depressive disorder is typically treated with selective serotonin reuptake inhibitors
(SSRIs), however, SSRIs take approximately six weeks to produce therapeutic effects, if any …
(SSRIs), however, SSRIs take approximately six weeks to produce therapeutic effects, if any …
[HTML][HTML] Acute psilocybin increased cortical activities in rats
Psilocybin, a naturally occurring hallucinogenic component of magic mushrooms, has
significant psychoactive effects in both humans and rodents. But the underlying mechanisms …
significant psychoactive effects in both humans and rodents. But the underlying mechanisms …
Isoflurane, ketamine-xylazine, and urethane markedly alter breathing even at subtherapeutic doses
CA Massey, GB Richerson - Journal of neurophysiology, 2017 - journals.physiology.org
Anesthetics are widely used for animal research on respiratory control in vivo, but their effect
on breathing and CO2 chemoreception has not been well characterized in mice, a species …
on breathing and CO2 chemoreception has not been well characterized in mice, a species …
Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice
A Bhandare, J van de Wiel, R Roberts, I Braren… - Elife, 2022 - elifesciences.org
Regulation of systemic PCO 2 is a life-preserving homeostatic mechanism. In the medulla
oblongata, the retrotrapezoid nucleus (RTN) and rostral medullary Raphe are proposed as …
oblongata, the retrotrapezoid nucleus (RTN) and rostral medullary Raphe are proposed as …
Volatile anesthetics activate a leak sodium conductance in retrotrapezoid nucleus neurons to maintain breathing during anesthesia in mice
Y Yang, M Ou, J Liu, W Zhao, L Zhuoma, Y Liang… - …, 2020 - pubs.asahq.org
Background Volatile anesthetics moderately depress respiratory function at clinically
relevant concentrations. Phox2b-expressing chemosensitive neurons in the retrotrapezoid …
relevant concentrations. Phox2b-expressing chemosensitive neurons in the retrotrapezoid …
The role of neurotransmitters in anesthesia
A Najafi, F Etezadi, RS Moharari… - … and Critical Care, 2017 - aacc.tums.ac.ir
General anesthetic drugs produce extensive neuronal changes in the central nervous
system by enhancing inhibitory and reducing excitatory neurotransmission. The major …
system by enhancing inhibitory and reducing excitatory neurotransmission. The major …
Marmoset Serotonin 5-HT1A Receptor Mapping with a Biased Agonist PET Probe 18F-F13714: Comparison with an Antagonist Tracer 18F-MPPF in Awake and …
C Yokoyama, A Mawatari, A Kawasaki… - International Journal …, 2016 - academic.oup.com
Background: In vivo mapping by positron emission tomography of the serotonin 1A receptors
has been hindered by the lack of suitable agonist positron emission tomography probes …
has been hindered by the lack of suitable agonist positron emission tomography probes …
[HTML][HTML] Effect of portal glucose sensing on systemic glucose levels in SD and ZDF rats
A Pal, DB Rhoads, A Tavakkoli - PLoS One, 2016 - journals.plos.org
Background The global epidemic of Type-2-Diabetes (T2D) highlights the need for novel
therapeutic targets and agents. Roux-en-Y-Gastric-Bypass (RYGB) is the most effective …
therapeutic targets and agents. Roux-en-Y-Gastric-Bypass (RYGB) is the most effective …