Skeletal muscle fibers are classified into fiber types, in particular, slow twitch versus fast
twitch. Muscle fiber types are generally defined by the particular myosin heavy chain …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Although hypoxia is a major stress on physiological processes, several human populations
have survived for millennia at high altitudes, suggesting that they have adapted to hypoxic …

A therapeutic approach for Duchenne muscular dystrophy (DMD) is to up-regulate utrophin
in skeletal muscle in an effort to compensate for the lack of dystrophin. We previously …

Duchenne muscular dystrophy (DMD) is a fatal, genetic disorder whose relentless
progression underscores the urgency for developing a cure. Although Duchenne initiated …

Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disorder for which there is
currently no effective treatment. This disorder is caused by mutations or deletions in the …

Muscular dystrophies are genetically diverse but share common phenotypic features of
muscle weakness, degeneration, and progressive decline in muscle function. Previous work …

Utrophin has been studied extensively in recent years in an effort to find a cure for
Duchenne muscular dystrophy. In this context, we previously showed that mice expressing …

Utrophin levels have recently been shown to be more abundant in slow vs. fast muscles, but
the nature of the molecular events underlying this difference remains to be fully elucidated …

Slower, more oxidative muscle fibers are more resistant to the dystrophic pathology in
Duchenne muscular dystrophy (DMD) patients as well as in the preclinical mdx mouse …