Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol,
which has widespread actions throughout the body. Calcitriol regulates numerous cellular …

Calcitriol, the hormonally active form of vitamin D, is being evaluated in clinical trials as an
anti-cancer agent. Calcitriol exerts multiple anti-proliferative, pro-apoptotic, and pro …

Cyclin-dependent kinase-2 (CDK2) is a member of protein kinase family. It plays an
important role in regulating various events of eukaryotic cell division cycle. Accumulated …

Oral cancer is known as one of the most common cancers, with a poor prognosis, related to
delayed clinical diagnosis, either due to the lack of particular biomarkers related to the …

In the last two decades vitamin D (VD) research has demonstrated new extraskeletal actions
of this pre-hormone, suggesting a protective role of this secosteroid in the onset, progression …

Ultraviolet B (UVB), in addition to having carcinogenic activity, is required for the production
of vitamin D3 (D3) in the skin which supplies> 90% of the body's requirement. Vitamin D is …

Background PCA3 is a non-coding RNA (ncRNA) that is highly expressed in prostate cancer
(PCa) cells, but its functional role is unknown. To investigate its putative function in PCa …

Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides
their well-known calcium-related functions, may also exert antiproliferative, pro …

Vitamin D is a steroid hormone crucial for bone mineral metabolism. In addition, vitamin D
has pleiotropic actions in the body, including anti-cancer actions. These anti-cancer …

An uncontrolled cell cycle is an obvious marker of tumor cells. The G1‑S phase is an
important restriction point in the normal cell cycle, but in cancer cells the restriction function …