Therapeutic drug measurement of mycophenolic acid derivatives in transplant patients

FA Elbarbry, AS Shoker - Clinical biochemistry, 2007 - Elsevier
INTRODUCTION:: Mycophenolic acid, the active metabolite of the prodrug mycophenolate
mofetil, is widely used as an immunosuppressive agent in transplant patients for the …

Omeprazole impairs the absorption of mycophenolate mofetil but not of enteric‐coated mycophenolate sodium in healthy volunteers

MG Kees, T Steinke, S Moritz… - The Journal of …, 2012 - Wiley Online Library
In 2 crossover studies, 12 healthy volunteers (6 male/6 female) received a single oral dose
of mycophenolate mofetil (MMF) 1000 mg or an equimolar dose of enteric‐coated …

[HTML][HTML] Clinical mycophenolic acid monitoring in liver transplant recipients

H Chen, B Chen - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
In liver transplantation, the efficacy of mycophenolate mofetil (MMF) has been confirmed in
clinical trials and studies. However, therapeutic drug monitoring for mycophenolic acid …

Sensitive rapid fluorescence polarization immunoassay for free mycophenolic acid determination in human serum and plasma

B Glahn-Martínez, E Benito-Peña, F Salis… - Analytical …, 2018 - ACS Publications
In this Article, we describe a fluorescence polarization immunoassay (FPIA) using a new
label—near-infrared fluorescent dye. The developed FPIA method was optimized for the …

UPLC MS/MS method for quantification of mycophenolic acid and metabolites in human plasma: application to pharmacokinetic study

X Delavenne, L Juthier, B Pons, C Mariat, T Basset - Clinica chimica acta, 2011 - Elsevier
BACKGROUND: We described the development and full validation of a rapid, high
throughput sensible and accurate UPLC method using tandem mass spectrometry detection …

High-performance liquid chromatography method for the determination of mycophenolic acid and its acyl and phenol glucuronide metabolites in human plasma

CG Patel, F Akhlaghi - Therapeutic drug monitoring, 2006 - journals.lww.com
Measuring the concentration of the pharmacologically active metabolite of mycophenolic
acid (MPA), acyl-MPAG (AcMPAG), in addition to the pharmacologically inactive phenol …

Establishment of high-performance liquid chromatography and enzyme multiplied immunoassay technology methods for determination of free mycophenolic acid and …

B Chen, ZD Gu, H Chen, WX Zhang… - Therapeutic drug …, 2010 - journals.lww.com
The objective of this study is to investigate the correlation between methods of high-
performance liquid chromatography (HPLC) and enzyme multiplied immunoassay …

An isocratic high performance liquid chromatographic method for quantification of mycophenolic acid and its glucuronide metabolite in human serum using liquid …

G Bahrami, B Mohammadi - Clinica Chimica Acta, 2006 - Elsevier
BACKGROUND: Mycophenolate mofetil (MMF) is a morpholinoethyl ester of mycophenolic
acid (MPA), which is widely used as an immunosuppressive agent in renal transplant …

Development and validation of an LC/MS/MS assay for mycophenolic acid in human peripheral blood mononuclear cells

H Bénech, S Hascoët, V Furlan, A Pruvost… - … of Chromatography B, 2007 - Elsevier
The aim was to develop a LC/MS/MS method able to quantify mycophenolic acid (MPA) in
the peripheral blood mononuclear cells (PBMCs) of transplanted patients. PBMCs were …

Liquid chromatographic determination of mycophenolic acid and its metabolites in human kidney transplant plasma: pharmacokinetic application

FA Elbarbry, AS Shoker - Journal of Chromatography B, 2007 - Elsevier
BACKGROUND AND OBJECTIVE: Difference in the hydrophilic properties of mycophenolic
acid metabolites makes it technically difficult to simultaneously determine their plasma levels …