The indole ring system is present in many natural products, pharmaceuticals,
agrochemicals, and other compounds of importance. 1–8 The indole unit forms the basis for …

Bis (indolyl) methane skeleton is the main building block of many naturally occurring
bioactive compounds. Bis (indolyl) methanes are found to possess a wide range of …

This article describes discovery of 29 novel bisindolylmethanes consisting of thiourea
moiety, which had been synthesized through three steps. These novel bisindolylmethane …

Spinal muscular atrophy (SMA) is an autosomal recessive disease of childhood due to loss
of the telomeric survival motor neuron gene, SMN1. The general functions of the main SMN1 …

For the first time, gluconic acid aqueous solution (GAAS), a biobased weakly acidic liquid,
was used as an effective promoting medium for organic reactions, such as the Michael …

Background: The bis (indolyl) methanes (BIMs) scaffold is reported for wide varieties of
pharmacological profiles, including antibacterial, anti-proliferative, anticancer, cytotoxic …

Retinoic acid and natural as well as synthetic derivatives (retinoids) are promising anti-
neoplastic agents endowed with both therapeutic and chemopreventive potential. Although …

From a synthetic perspective, bis (indolyl) methanes have undergone extensive
investigation over the past two to three decades owing to their remarkable pharmacological …

Retinoid-related molecules (RRMs) are derivatives of retinoic acid and promising
antileukemic agents with a mechanism of action different from that of other common …

Bisindole analogs 1–17 were synthesized and evaluated for their in vitro β-glucuronidase
inhibitory potential. Out of seventeen compounds, the analog 1 (IC 50= 1.62±0.04 μM), 6 (IC …