[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
Spotlight on protein N-terminal acetylation
N-terminal acetylation (Nt-acetylation) is a widespread protein modification among
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
Deorphanizing caspase-3 and caspase-9 substrates in and out of apoptosis with deep substrate profiling
Caspases are a family of enzymes that regulate biological processes such as inflammation
and programmed cell death, through proteolysis. For example, in the intrinsic pathway of …
and programmed cell death, through proteolysis. For example, in the intrinsic pathway of …
Protein analysis by shotgun/bottom-up proteomics
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides
JM Chick, D Kolippakkam, DP Nusinow, B Zhai… - Nature …, 2015 - nature.com
Fewer than half of all tandem mass spectrometry (MS/MS) spectra acquired in shotgun
proteomics experiments are typically matched to a peptide with high confidence. Here we …
proteomics experiments are typically matched to a peptide with high confidence. Here we …
Kepler planet-detection mission: introduction and first results
The Kepler mission was designed to determine the frequency of Earth-sized planets in and
near the habitable zone of Sun-like stars. The habitable zone is the region where planetary …
near the habitable zone of Sun-like stars. The habitable zone is the region where planetary …
The N‐end rule pathway and regulation by proteolysis
A Varshavsky - Protein science, 2011 - Wiley Online Library
The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …
Improved visualization of protein consensus sequences by iceLogo
To the Editor: Large sequence-based datasets are often scanned for conserved sequence
patterns to extract useful biological information1. Sequence logos2 have been developed to …
patterns to extract useful biological information1. Sequence logos2 have been developed to …
First things first: vital protein marks by N-terminal acetyltransferases
N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …