The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …

The functional and structural concept of tight junctions has developed after discovery of
claudin and TAMP proteins. Many of these proteins contribute to epi-and endothelial barrier …

The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence
implicates a role for defective calcium reabsorption in the renal proximal tubule. We …

Sequential expression of claudins, a family of tight junction proteins, along the nephron
mirrors the sequential expression of ion channels and transporters. Only by the interplay of …

The X chromosome is a key player in germ cell development, as has been highlighted for
males in previous studies revealing that the mammalian X chromosome is enriched in genes …

Claudin-5 is the most enriched tight junction protein at the blood–brain barrier. Perturbations
in its levels of expression have been observed across numerous neurological and …

Claudin-2 is a tight junction protein expressed in leaky epithelia where it forms paracellular
pores permeable to cations and water. The paracellular pore formed by claudin-2 is …

Magnesium is the fourth most abundant cation in the body. It plays a critical role in many
biological processes, including the process of energy release. Paracellular transport of …

Claudins are tight junction proteins mostly appreciated in their function of paracellular
barrier-formation. Compared to a virtual absence of any tight junctions, their paracellular …

The 24 claudin (CLDN) genes in the human genome encode 26 representative CLDN family
proteins. CLDNs are tetraspan‑transmembrane proteins at tight junctions. Because several …