Complex multicellular organisms, such as mammals, express two complete sets of
chromosomes per nucleus, combining the genetic material of both parents. However …

Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive or non-Mendelian trait or may present as a …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

Genomic imprinting affects a subset of genes in mammals and results in a monoallelic,
parental-specific expression pattern. Most of these genes are located in clusters that are …

X chromosome inactivation and genomic imprinting are classic epigenetic processes that
cause disease when not appropriately regulated in mammals. Whereas X chromosome …

DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …