Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease
In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …
technically challenging beginnings to become common laboratory methods capable of …
Optimal transport for single-cell and spatial omics
High-throughput single-cell profiling provides an unprecedented ability to uncover the
molecular states of millions of cells. These technologies are, however, destructive to cells …
molecular states of millions of cells. These technologies are, however, destructive to cells …
Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response
Background Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in
cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the …
cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the …
Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism
Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated
fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid …
fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid …
Fully-automated and ultra-fast cell-type identification using specific marker combinations from single-cell transcriptomic data
Identification of cell populations often relies on manual annotation of cell clusters using
established marker genes. However, the selection of marker genes is a time-consuming …
established marker genes. However, the selection of marker genes is a time-consuming …
Learning single-cell perturbation responses using neural optimal transport
Understanding and predicting molecular responses in single cells upon chemical, genetic or
mechanical perturbations is a core question in biology. Obtaining single-cell measurements …
mechanical perturbations is a core question in biology. Obtaining single-cell measurements …
[HTML][HTML] TGFBI secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-Src-Stat3 signaling
P Peng, H Zhu, D Liu, Z Chen, X Zhang, Z Guo… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: In the glioblastoma (GBM) microenvironment, tumor-associated macrophages
(TAMs) are prominent components and facilitate tumor growth. The exact molecular …
(TAMs) are prominent components and facilitate tumor growth. The exact molecular …
[HTML][HTML] Machine learning for perturbational single-cell omics
Cell biology is fundamentally limited in its ability to collect complete data on cellular
phenotypes and the wide range of responses to perturbation. Areas such as computer vision …
phenotypes and the wide range of responses to perturbation. Areas such as computer vision …
scPerturb: harmonized single-cell perturbation data
Abstract Analysis across a growing number of single-cell perturbation datasets is hampered
by poor data interoperability. To facilitate development and benchmarking of computational …
by poor data interoperability. To facilitate development and benchmarking of computational …
Single-cell analysis of 5-aminolevulinic acid intraoperative labeling specificity for glioblastoma
OBJECTIVE Glioblastoma (GBM) is the most common and aggressive malignant primary
brain tumor, and resection is a key part of the standard of care. In fluorescence-guided …
brain tumor, and resection is a key part of the standard of care. In fluorescence-guided …