Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups, this diversity encompasses a rich discovery potential for …

Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …

The tetrazine ligation is an inverse electron-demand Diels–Alder reaction widely used for
bioorthogonal modifications due to its versatility, site specificity and fast reaction kinetics. A …

Microbial natural products constitute a wide variety of chemical compounds, many which can
have antibiotic, antiviral, or anticancer properties that make them interesting for clinical …

Recently developed bioinformatic tools have bolstered the discovery of ribosomally
synthesized and post-translationally modified peptides (RiPPs). Using an improved version …

Lipopeptides represent a large group of microbial natural products that include important
antibacterial and antifungal drugs and some of the most-powerful known biosurfactants. The …

The past decade has seen impressive advances in understanding the biosynthesis of
ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most …

Peptide-derived cyclophanes inhabit a unique niche in the chemical space of macrocyclic
peptides with several examples of pharmaceutical importance. Although both synthetic and …