Although it has long been recognized that the exonucleolytic proofreading activity intrinsic to
the replicative DNA polymerases Pol δ and Pol ε is essential for faithful replication of DNA …

The information encoded in DNA is influenced by the presence of non-canonical
nucleotides, the most frequent of which are ribonucleotides. In this Review, we discuss …

The fidelity of DNA replication is determined by many factors, here simplified as the
contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch …

Cancer was recognized as a genetic disease at least four decades ago, with the realization
that the spontaneous mutation rate must increase early in tumorigenesis to account for the …

A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate
(dNTP) levels within a range that is optimal for chromosomal replication. Since DNA …

Context.—Cancer immunotherapy provides unprecedented rates of durable clinical benefit
to late-stage cancer patients across many tumor types, but there remains a critical need for …

Metabolism is a fundamental cellular process that can become harmful for cells by leading to
DNA damage, for instance by an increase in oxidative stress or through the generation of …

Even small variations in dNTP concentrations decrease DNA replication fidelity, and this
observation prompted us to analyze genomic cancer data for mutations in enzymes involved …

The evolutionarily conserved human polymerase delta (POLD1) gene encodes the large
p125 subunit which provides the essential catalytic activities of polymerase δ (Polδ) …

The fidelity of DNA replication relies on three error avoidance mechanisms acting in series:
nucleotide selectivity of replicative DNA polymerases, exonucleolytic proofreading, and post …