Biocatalytic cascades that involve enzymatic oxidation as one or more key steps are
powerful tools to access valuable chemicals with various functionalizations starting from …

We report the discovery of an unusual halohydrin dehalogenase, HHDHamb, that can work
under relatively low acidic conditions and extremely low temperatures for the bio‐nitration of …

Hydroxynitrile lyases (HNLs) primarily catalyze the stereoselective synthesis of
cyanohydrins, but some of them also carry out asymmetric nitroaldol synthesis (Henry …

New types of one‐pot multi‐step enzymatic cascade transformation involving dynamic
kinetic resolution to convert racemic substrates to chiral products in high ee and yield were …

Arabidopsis thaliana hydroxynitrile lyase (AtHNL) engineering has uncovered variants that
showed up to 12-fold improved catalytic efficiency than the wild-type towards asymmetric …

Enzyme catalysis has clear advantages in the process of oxidizing glucose to produce
gluconic acid. In the enzyme cascade, the improvement of the cascade efficiency is desired …

Diastereoselective Henry reaction (DHR) is an effective direct C–C bond ligation
transformation that enables the synthesis of β-nitroalcohols having two contiguous chiral …

The integration of organocatalysis and enzyme catalysis in one‐pot cascade processes
allows for the efficient construction of complex molecular architectures with high levels of …

Protein engineering to improve promiscuous catalytic activity is important for biocatalytic
application of enzymes in green synthesis. We uncovered the significance of binding site …

Biocatalysis has emerged as a strong tool for the synthesis of active pharmaceutical
ingredients (APIs). In the early twentieth century, whole cell biocatalysis was used to …