Abnormal interactions and misfolding of synaptic proteins in the nervous system are being
extensively explored as important pathogenic events resulting in neurodegeneration in …

Parkinson's disease is the second most common neurodegenerative disease, after
Alzheimer's disease. Neuropathologically, it is characterized by the degeneration of …

Neuronal and oligodendrocytic aggregates of fibrillar α-synuclein define several diseases of
the nervous system. It is likely that these inclusions impair vital metabolic processes and …

α-, β-, and γ-Synuclein, a novel family of neuronal proteins, has become the focus of
research interest because α-synuclein has been increasingly implicated in the pathogenesis …

Mutations in the α-synuclein (αSYN) gene are associated with rare cases of familial
Parkinson's disease, and αSYN is a major component of Lewy bodies and Lewy neurites …

Accumulation of α‐synuclein has been associated with neurodegenerative disorders, such
as Lewy body disease and multiple system atrophy. We previously showed that expression …

Abnormal accumulation of the presynaptic protein α-synuclein has recently been implicated
in the pathogenesis of Alzheimer's and Parkinson's diseases. Because neurodegeneration …

α-Synuclein is a major component of the fibrillary lesion known as Lewy bodies and Lewy
neurites that are the pathologic hallmarks of Parkinson's disease (PD). In addition, point …

An abundant presynaptic protein, α-synuclein, is centrally involved in the pathogenesis of
Parkinson's disease. However, conflicting data exist about the normal function of α …

Retinal remodeling is a progressive series of negative plasticity revisions that arise from
retinal degeneration, and are seen in retinitis pigmentosa, age-related macular …