A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities
Rhodanines are accepted as advantaged heterocycles in medicinal chemistry as one of the
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …
[HTML][HTML] Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives
LJ Yin, AKD bin Ahmad Kamar, GT Fung… - Biomedicine & …, 2022 - Elsevier
Rhodanine has been recognized as a privileged scaffold in medicinal chemistry due to its
well-known ability to demonstrate a broad range of biological activities. The possibility of …
well-known ability to demonstrate a broad range of biological activities. The possibility of …
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
A Toumi, S Boudriga, K Hamden, M Sobeh… - Bioorganic …, 2021 - Elsevier
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes
mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine …
mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine …
α‐glucosidase, α‐amylase inhibition, kinetics and docking studies of novel (2‐chloro‐6‐(trifluoromethyl) benzyloxy) arylidene) based rhodanine and rhodanine acetic …
V Kumar, R Ramu, PS Shirahatti, VBC Kumari… - …, 2021 - Wiley Online Library
In our effort to identify potent fluorinated small molecules as antidiabetic compounds, a novel
fluorinated series of 2‐chloro‐6‐(trifluoromethyl) benzyloxy arylidene derived Rhodanine …
fluorinated series of 2‐chloro‐6‐(trifluoromethyl) benzyloxy arylidene derived Rhodanine …
Piperonyl-Tethered Rhodanine Derivatives Potently Inhibit Chitinolytic Enzymes of Ostrinia furnacalis
Q Han, N Wu, YY Liu, JY Zhang, RL Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Insect pest chitinases are potential target for developing new insect growth regulators.
Piperine was found first to inhibit the insect chitinase (Of Chi-h) from Ostrinia furnacalis …
Piperine was found first to inhibit the insect chitinase (Of Chi-h) from Ostrinia furnacalis …
Exploring innovative strategies for identifying anti-breast cancer compounds by integrating 2D/3D-QSAR, molecular docking analyses, ADMET predictions, molecular …
S El Rhabori, M Alaqarbeh, YEL Allouche… - Journal of Molecular …, 2024 - Elsevier
Breast cancer is a crucial global health issue, representing the most frequent cancer and a
major cause of cancer-related mortality of women. The difficulty of treating this disease is …
major cause of cancer-related mortality of women. The difficulty of treating this disease is …
Anticancer profile of rhodanines: Structure–activity relationship (SAR) and molecular targets—A review
J Szczepański, H Tuszewska, N Trotsko - Molecules, 2022 - mdpi.com
The rhodanine core is a well-known privileged heterocycle in medicinal chemistry. The
rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity …
rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity …
Design and synthesis of new CDK2 inhibitors containing thiazolone and thiazolthione scafold with apoptotic activity
NEA Abd El-Sattar, EHK Badawy… - Chemical and …, 2021 - jstage.jst.go.jp
Abstract Cyclin dependent kinase 2 (CDK2) inhibition is a well-established strategy for
treating cancer. Different series of novel thiazolone (1, 7–9) together with fused thiazolthione …
treating cancer. Different series of novel thiazolone (1, 7–9) together with fused thiazolthione …
New N-ribosides and N-mannosides of rhodanine derivatives with anticancer activity on leukemia cell line: Design, synthesis, DFT and molecular modelling studies
N-ribosylation and N-mannosylation compounds have a great role in compounds activity as
anticancer. The reaction of 2-thioxo-4-thiazolidinone (rhodanine) derivatives, as aglycon …
anticancer. The reaction of 2-thioxo-4-thiazolidinone (rhodanine) derivatives, as aglycon …
Comparative α-glucosidase and α-amylase inhibition studies of rhodanine–pyrazole conjugates and their simple rhodanine analogues
Novel rhodanine–pyrazole conjugates (6a–i) and their simple rhodanine analogues (8a–e)
were prepared and comparatively screened for their antidiabetic activities against enzymatic …
were prepared and comparatively screened for their antidiabetic activities against enzymatic …