A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities

SM Mousavi, M Zarei, SA Hashemi… - Artificial cells …, 2019 - Taylor & Francis
Rhodanines are accepted as advantaged heterocycles in medicinal chemistry as one of the
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …

[HTML][HTML] Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives

LJ Yin, AKD bin Ahmad Kamar, GT Fung… - Biomedicine & …, 2022 - Elsevier
Rhodanine has been recognized as a privileged scaffold in medicinal chemistry due to its
well-known ability to demonstrate a broad range of biological activities. The possibility of …

Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors

A Toumi, S Boudriga, K Hamden, M Sobeh… - Bioorganic …, 2021 - Elsevier
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes
mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine …

α‐glucosidase, α‐amylase inhibition, kinetics and docking studies of novel (2‐chloro‐6‐(trifluoromethyl) benzyloxy) arylidene) based rhodanine and rhodanine acetic …

V Kumar, R Ramu, PS Shirahatti, VBC Kumari… - …, 2021 - Wiley Online Library
In our effort to identify potent fluorinated small molecules as antidiabetic compounds, a novel
fluorinated series of 2‐chloro‐6‐(trifluoromethyl) benzyloxy arylidene derived Rhodanine …

Piperonyl-Tethered Rhodanine Derivatives Potently Inhibit Chitinolytic Enzymes of Ostrinia furnacalis

Q Han, N Wu, YY Liu, JY Zhang, RL Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Insect pest chitinases are potential target for developing new insect growth regulators.
Piperine was found first to inhibit the insect chitinase (Of Chi-h) from Ostrinia furnacalis …

Exploring innovative strategies for identifying anti-breast cancer compounds by integrating 2D/3D-QSAR, molecular docking analyses, ADMET predictions, molecular …

S El Rhabori, M Alaqarbeh, YEL Allouche… - Journal of Molecular …, 2024 - Elsevier
Breast cancer is a crucial global health issue, representing the most frequent cancer and a
major cause of cancer-related mortality of women. The difficulty of treating this disease is …

Anticancer profile of rhodanines: Structure–activity relationship (SAR) and molecular targets—A review

J Szczepański, H Tuszewska, N Trotsko - Molecules, 2022 - mdpi.com
The rhodanine core is a well-known privileged heterocycle in medicinal chemistry. The
rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity …

Design and synthesis of new CDK2 inhibitors containing thiazolone and thiazolthione scafold with apoptotic activity

NEA Abd El-Sattar, EHK Badawy… - Chemical and …, 2021 - jstage.jst.go.jp
Abstract Cyclin dependent kinase 2 (CDK2) inhibition is a well-established strategy for
treating cancer. Different series of novel thiazolone (1, 7–9) together with fused thiazolthione …

New N-ribosides and N-mannosides of rhodanine derivatives with anticancer activity on leukemia cell line: Design, synthesis, DFT and molecular modelling studies

AI Khodair, MK Awad, JP Gesson, YAMM Elshaier - Carbohydrate research, 2020 - Elsevier
N-ribosylation and N-mannosylation compounds have a great role in compounds activity as
anticancer. The reaction of 2-thioxo-4-thiazolidinone (rhodanine) derivatives, as aglycon …

Comparative α-glucosidase and α-amylase inhibition studies of rhodanine–pyrazole conjugates and their simple rhodanine analogues

P Singh, S Mothilal, N Kerru, A Singh-Pillay… - Medicinal Chemistry …, 2019 - Springer
Novel rhodanine–pyrazole conjugates (6a–i) and their simple rhodanine analogues (8a–e)
were prepared and comparatively screened for their antidiabetic activities against enzymatic …