Psychiatric disorders such as autism and schizophrenia, arise from abnormalities in brain
systems that underlie cognitive, emotional, and social functions. The brain is enormously …

The neurobiology of schizophrenia involves multiple facets of pathophysiology, ranging from
its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level …

Neurons in the primate dorsolateral prefrontal cortex (dlPFC) generate persistent firing in the
absence of sensory stimulation, the foundation of mental representation. Persistent firing …

Neuroinflammatory disorders preferentially impair the higher cognitive and executive
functions of the prefrontal cortex (PFC). This includes such challenging disorders as …

Rationale Aberrant prefrontal-hippocampal (PFC-HC) connectivity is disrupted in several
psychiatric and at-risk conditions. Advances in rodent functional imaging have opened the …

The common marmoset (Callithrix jacchus) is a New World primate that is becoming
increasingly popular as a preclinical model. To assess functional connectivity (FC) across …

The synaptic balance between excitation and inhibition (E/I balance) is a fundamental
principle of cortical circuits, and disruptions in E/I balance are commonly linked to cognitive …

Acetylcholine release in the prefrontal cortex (PFC), acting through muscarinic receptors,
has an essential role in regulating flexible behavior and working memory (WM). General …

Many tasks demand that information is kept online for a few seconds before it is used to
guide behavior. The information is kept in working memory as the persistent firing of neurons …

We employed multi-electrode array recording to evaluate the influence of NMDA receptors
(NMDAR) on spike-timing dynamics in prefrontal networks of monkeys as they performed a …