[HTML][HTML] NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

The liver as an endocrine organ—linking NAFLD and insulin resistance

MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

miRNAs and NAFLD: from pathophysiology to therapy

M Gjorgjieva, C Sobolewski, D Dolicka, MC de Sousa… - Gut, 2019 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is associated with a thorough reprogramming of
hepatic metabolism. Epigenetic mechanisms, in particular those associated with …

[HTML][HTML] Clinical and molecular biomarkers for diagnosis and staging of NAFLD

S Di Mauro, A Scamporrino, A Filippello… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common hepatic pathology in
industrialized countries, affecting about 25% of the general population. NAFLD is a benign …

Epigenetics in NAFLD/NASH: Targets and therapy

N Sodum, G Kumar, SL Bojja, N Kumar… - Pharmacological …, 2021 - Elsevier
Recently non-alcoholic fatty liver disease (NAFLD) has grabbed considerable scientific
attention, owing to its rapid increase in prevalence worldwide and growing burden on end …

[HTML][HTML] miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease

JK Long, W Dai, YW Zheng, SP Zhao - Molecular Medicine, 2019 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a common hepatic disease with an
increasing prevalence but an unclear aetiology. This study aimed to investigate the …

The role of exosomal miRNA in nonalcoholic fatty liver disease

A Mahmoudi, AE Butler… - Journal of cellular …, 2022 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) impacts more than one‐third of the population and
is linked with other metabolic diseases. The term encompasses a wide spectrum of …

[HTML][HTML] Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

K Johnson, PJ Leary, O Govaere, MJ Barter… - JHEP Reports, 2022 - Elsevier
Background & Aims Serum microRNA (miRNA) levels are known to change in non-alcoholic
fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile …

[HTML][HTML] The emerging role of microRNAs in NAFLD: highlight of microRNA-29a in modulating oxidative stress, inflammation, and beyond

HY Lin, YL Yang, PW Wang, FS Wang, YH Huang - Cells, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and
ranges from steatosis to steatohepatitis and to liver fibrosis. Lipotoxicity in hepatocytes …

Multifaced roles of desmoplastic reaction and fibrosis in pancreatic cancer progression: Current understanding and future directions

H Sato, T Hara, S Meng, Y Tsuji, Y Arao… - Cancer …, 2023 - Wiley Online Library
Desmoplastic reaction is a fibrosis reaction that is characterized by a large amount of dense
extracellular matrix (ECM) and dense fibrous stroma. Fibrotic stroma around the tumor has …