Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and
one oxygen atom. The 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole have favourable physical …

Abstract Sirtuin 2 (SIRT2) is a member of the human sirtuins, which regulates various
biological processes and is deemed as a novel biomarker for different cancers. Depending …

Abstract Sirtuin 2 (SIRT2) is involved in a wide range of processes, from transcription to
metabolism to genome stability. Dysregulation of SIRT2 has been associated with the …

Sirtuin isoform 2 (SIRT2) is one of the seven sirtuin isoforms present in humans, being
classified as class III histone deacetylases (HDACs). Based on the high sequence similarity …

The development of environment-friendly new Poly-adenosine diphosphate (ADP)-ribose
Polymerase (PARP) inhibitors are highly essential because of their involvement in the …

Abstract Compound,(E)-5-(4-((thiophen-2-ylmethylene) amino) phenyl)-1, 3, 4-oxadiazole-2-
thiol (3) was synthesized via condensation reaction of 5-(4-aminophenyl)-1, 3, 4-oxadiazole …

The incidence and mortality of cancer continue to grow since the current medical treatments
often fail to produce a complete and durable tumor response and ultimately give rise to …

Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer
worldwide. Therapeutic strategies are still challenging due to the high relapse rate after …

Epigenetic modifications play an essential role in tumor suppression and promotion. Among
the diverse range of epigenetic regulators, SIRT2, a member of NAD+-dependent protein …

The increased expression of VEGFR‐2 in a variety of cancer cells promotes a cascade of
cellular responses that improve cell survival, growth, and proliferation. Heterocycles are …