Kappa-opioid receptors (KOR) are widely expressed throughout the central nervous system,
where they modulate a range of physiological processes depending on their location …

Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the
discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9 …

Kappa opioid receptor (KOR) is a member of the opioid receptor system, the G protein-
coupled receptors that are expressed throughout the peripheral and central nervous …

Pain remains a very pervasive problem throughout medicine. Classical pain management is
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …

Strong opioid analgesics, including morphine, are the mainstays for treating moderate to
severe acute pain and alleviating chronic cancer pain. However, opioid-related adverse …

The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid
receptor, an emerging target for next-generation analgesics. Here we review analogs of the …

Chronic itch is one of the disturbing symptoms of inflammatory skin diseases. Kappa opioid
receptor agonists are effective in suppressing scratching in mice against different …

Salvia divinorum Epling and Játiva is a perennial mint from the Lamiaceae family, endemic
to Mexico, predominantly from the state of Oaxaca. Due to its psychoactive properties, S …

In the search for safer, non-addictive analgesics, kappa opioid receptor (KOPr) agonists are
a potential target, as unlike mu-opioid analgesics, they do not have abuse potential …

The acute activation of kappa opioid receptors (KOPr) produces antinociceptive and anti-
cocaine effects, however, their side-effects have limited further clinical development. Mesyl …