The hypothalamic peptide oxytocin and its receptor are involved in a range of physiological
processes, including parturition, lactation, cell growth, wound healing, and social behavior …

Obesity and substantially increased risk of metabolic diseases have become a global
epidemic. microRNAs have attracted a great deal of attention as a potential therapeutic …

Adipose tissue undergoes thermogenic remodeling in response to thermal stress and
metabolic cues, playing a crucial role in regulating energy expenditure and metabolic …

Mammals maintain thermoregulation in the face of cold environmental temperatures by
activating bioenergetic mechanisms that increase heat production. Included in this response …

Although the adipose tissue (AT) is a central metabolic organ in the regulation of whole-
body energy homeostasis, it is also an important endocrine and immunological organ. As an …

We report the first and enantioselective total syntheses of (+)-1-deacetylcaesalmin C,(+)-δ-
caesalpin,(+)-norcaesalpinin MC, and (+)-norcaesalpinin P. Salient features of the synthetic …

Insulin stimulates glucose uptake into adipocytes via mTORC2/AKT signaling and GLUT4
translocation and directs glucose carbons into glycolysis, glycerol for TAG synthesis, and de …

Human thermogenic adipose tissue has long been touted as a promising therapeutic target
for obesity and its associated metabolic diseases. Here, we provide a brief overview of the …

Thermogenic fat, consisting of brown and beige adipocytes, dissipates energy in the form of
heat, in contrast to the characteristics of white adipocytes that store energy. Increasing …

Mammals maintain a constant core body temperature through adaptive thermogenesis
which includes shivering and non-shivering thermogenesis. Non-shivering thermogenesis …