Type III interferons in hepatitis C virus infection
M Boisvert, NH Shoukry - Frontiers in immunology, 2016 - frontiersin.org
The interferon (IFN)-λ family of type III cytokines includes the closely related interleukin (IL)-
28A (IFN-λ2), IL-28B (IFN-λ3), and IL-29 (IFN-λ1). They signal through the Janus kinases …
28A (IFN-λ2), IL-28B (IFN-λ3), and IL-29 (IFN-λ1). They signal through the Janus kinases …
Role of interferons in chronic hepatitis C infection
C Scagnolari, K Monteleone, G Cacciotti… - Current drug …, 2017 - ingentaconnect.com
It is known that the production of and/or response to interferon (IFN) are deregulated during
chronic hepatitis C virus (HCV) infection. In particular, several studies have shown that …
chronic hepatitis C virus (HCV) infection. In particular, several studies have shown that …
Interferon-lambda 3 and 4 polymorphisms increase sustained virological responses and regulate innate immunity in antiviral therapy with pegylated interferon-alpha
AMV Silva, LE Alvarado-Arnez, T Azamor… - Frontiers in Cellular …, 2021 - frontiersin.org
Sustained virologic response (SVR) in chronic hepatitis C (CHC) treatment denotes that the
host genetics controls the immune response and unequivocally contribute to viral clearance …
host genetics controls the immune response and unequivocally contribute to viral clearance …
A multifaceted computational report on the variants effect on KIR2DL3 and IFNL3 candidate gene in HCV clearance
HCV infection causes acute and chronic liver diseases including, cirrhosis and
hepatocellular carcinoma. Following HCV infection, spontaneous clearance occurs in …
hepatocellular carcinoma. Following HCV infection, spontaneous clearance occurs in …
Role of some predominant host immunomodulators' single nucleotide polymorphisms in severity of hepatitis B virus and hepatitis C virus infection
Hepatitis B and C infections can be either acute or chronic. The chronic infection can
culminate in liver cirrhosis and hepatocellular carcinoma. Influence of the host genetic …
culminate in liver cirrhosis and hepatocellular carcinoma. Influence of the host genetic …
The presence of IFL3/4 rs12979860 C allele influences the in vitro IP-10 production by mononuclear cells from patients with systemic lupus erythematosus
Y Juárez-Vicuña, J Pérez-Ramos, L Adalid-Peralta… - Lupus, 2020 - journals.sagepub.com
Objective To explore whether the IFNL3/4 rs12979860 genotype may influence serum levels
or production of interferon-inducible protein-10 (IP-10) by peripheral blood mononuclear …
or production of interferon-inducible protein-10 (IP-10) by peripheral blood mononuclear …
A Knockout IFNL4 Variant Is Associated With Protection From Sexually Transmitted HIV-1 Infection
C Jaimes-Bernal, N Rallón, JM Benito… - The Journal of …, 2019 - academic.oup.com
An interferon λ4 gene (IFNL4) knockout allele (rs368234815; TT) is associated with
spontaneous and IFN-α–dependent cure of hepatitis C virus infection. The role of this …
spontaneous and IFN-α–dependent cure of hepatitis C virus infection. The role of this …
IFNL4 Genotype Does Not Associate with CD4 T-Cell Recovery in People Living with Human Immunodeficiency Virus
Immune non-responders (INRs) are people with HIV infection who fail to restore their CD4 T-
cell counts in spite of prolonged virologic suppression, a condition associated with higher …
cell counts in spite of prolonged virologic suppression, a condition associated with higher …
The evaluation of interferon lambda 4 rs368234815 as a predictor factor in treated patients with chronic hepatitis C genotype 1a infection
Context: Host factors including single-nucleotide polymorphisms (SNPs) in or near interferon
lambda (IFNL) gene are the important factors in predicting response to treatment of chronic …
lambda (IFNL) gene are the important factors in predicting response to treatment of chronic …
HCV 感染相关干扰素L4 真核表达载体的构建与表达
徐溪， 党引利， 吴朔 - 实用肝脏病杂志, 2018 - manu43.magtech.com.cn
目的构建HCV 感染相关干扰素IFNL4 蛋白融合His 标签的真核表达载体, 并将其在293-T
细胞中表达后进行初步纯化鉴定. 方法采用PCR 法从含人IFNL4 基因序列的质粒pFC14A-p179 …
细胞中表达后进行初步纯化鉴定. 方法采用PCR 法从含人IFNL4 基因序列的质粒pFC14A-p179 …