Nature has developed a plethora of protein machinery to operate and maintain nearly every
task of cellular life. These processes are tightly regulated via post‐expression modifications …

The proteasome is a multi-catalytic protease complex that is involved in protein quality
control via three proteolytic activities (ie, caspase-, trypsin-, and chymotrypsin-like activities) …

Summary E2-ubiquitin (Ub) conjugates are useful chemical biology tools for studying the E3
mechanisms, but so far, the reported systems have involved either no substrates or only …

The proteasome, the major protein-degradation machine in cells, regulates neuronal
synapses and long-term information storage. Here, using super-resolution microscopy, we …

Controlled degradation of proteins is necessary for ensuring their abundance and sustaining
a healthy and accurately functioning proteome. One of the degradation routes involves the …

Protein degradation is critical for brain function through processes that remain incompletely
understood. Here, we investigated the in vivo function of the 20S neuronal membrane …

For years, proteasomal degradation was predominantly attributed to the ubiquitin-26S
proteasome pathway. However, it is now evident that the core 20S proteasome can …

Peptides from degradation of intracellular proteins are continuously displayed by major
histocompatibility complex (MHC) class I. To better understand origins of these peptides, we …

Research in the past twenty years or so has revealed that neurons synthesize and degrade
proteins at their synapses to enable synaptic proteome remodelling on demand and in real …

Proteasomes are large macromolecular complexes with multiple distinct catalytic activities
that are each vital to human brain health and disease. Despite their importance …