Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability
YA Komarova, K Kruse, D Mehta, AB Malik - Circulation research, 2017 - Am Heart Assoc
The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …
Sphingolipid metabolites in inflammatory disease
M Maceyka, S Spiegel - Nature, 2014 - nature.com
Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …
An approach to spatiotemporally resolve protein interaction networks in living cells
BT Lobingier, R Hüttenhain, K Eichel, KB Miller… - Cell, 2017 - cell.com
Cells operate through protein interaction networks organized in space and time. Here, we
describe an approach to resolve both dimensions simultaneously by using proximity …
describe an approach to resolve both dimensions simultaneously by using proximity …
Passing the vascular barrier: endothelial signaling processes controlling extravasation
N Wettschureck, B Strilic… - Physiological …, 2019 - journals.physiology.org
A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …
lipid mediator that regulates many processes in vertebrate development, physiology, and …
Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate
Lysophospholipids are bioactive lipids and can signal through G-protein-coupled receptors
(GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and …
(GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and …
An update on the biology of sphingosine 1-phosphate receptors
Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …
Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs
JG Cyster, SR Schwab - Annual review of immunology, 2012 - annualreviews.org
Much has been learned about how cells enter lymphoid tissues. But how do they leave?
Sphingosine-1-phosphate (S1P) has emerged over the past decade as a central mediator of …
Sphingosine-1-phosphate (S1P) has emerged over the past decade as a central mediator of …
Biased ligands at G-protein-coupled receptors: promise and progress
JD Violin, AL Crombie, DG Soergel, MW Lark - Trends in pharmacological …, 2014 - cell.com
Drug discovery targeting G protein-coupled receptors (GPCRs) is no longer limited to
seeking agonists or antagonists to stimulate or block cellular responses associated with a …
seeking agonists or antagonists to stimulate or block cellular responses associated with a …