Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in
normal tissue turnover and is associated with a variety of age-related diseases, including …

The aging process significantly impacts lung physiology and is a major risk factor for chronic
respiratory diseases, including chronic obstructive pulmonary disease (COPD), idiopathic …

Background Telomere length, crucial for genomic stability, have been implicated in various
inflamm-aging diseases, but their role in sarcoidosis remains unexplored. Objective This …

Aging mechanisms, including telomere dysfunction and cellular senescence, likely
contribute to the progressive fibrosis, vasculopathy, and immune dysfunction of SSc. Further …

Objective Systemic sclerosis-interstitial lung disease (SSc-ILD) is the leading cause of death
in SSc, affecting around 50% of the patients. Lung tissue of patients with early-stage SSc …

The lungs are a principal factor in the increased morbidity and mortality observed in patients
with Connective Tissue Disease (CTD), frequently presenting as CTD-associated Interstitial …

In systemic sclerosis (SSc, or scleroderma), defective angiogenesis, clinically manifesting
with abnormal capillary architecture and severe capillary reduction, represents a hallmark of …

Macrophages are key regulators of tissue repair and fibrosis. Following injury, macrophages
undergo marked phenotypic and functional changes to play crucial roles throughout the …